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<p>Lung cancer screening (LCS) reduces mortality and involves vast multimodal data such as text, tables, and images. Fully mining such big data requires multitasking; otherwise, occult but important features may be overlooked, adversely affecting clinical management and healthcare quality. Here we propose a medical multimodal-multitask foundation model (M3FM) for three-dimensional low-dose computed tomography (CT) LCS. After curating a multimodal multitask dataset of 49 clinical data types, 163,725 chest CT series, and 17 tasks involved in LCS, we develop a scalable multimodal question-answering model architecture for synergistic multimodal multitasking. M3FM consistently outperforms the state-of-the-art models, improving lung cancer risk and cardiovascular disease mortality risk prediction by up to 20% and 10% respectively. M3FM processes multiscale high-dimensional images, handles various combinations of multimodal data, identifies informative data elements, and adapts to out-of-distribution tasks with minimal data. In this work, we show that M3FM advances various LCS tasks through large-scale multimodal and multitask learning.</p>

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Medical multimodal multitask foundation model for lung cancer screening

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月11日

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  • Chuang Niu,
  • Qing Lyu,
  • Christopher D. Carothers,
  • Parisa Kaviani,
  • Josh Tan,
  • Pingkun Yan,
  • Mannudeep K. Kalra,
  • Christopher T. Whitlow,
  • Ge Wang

摘要

Lung cancer screening (LCS) reduces mortality and involves vast multimodal data such as text, tables, and images. Fully mining such big data requires multitasking; otherwise, occult but important features may be overlooked, adversely affecting clinical management and healthcare quality. Here we propose a medical multimodal-multitask foundation model (M3FM) for three-dimensional low-dose computed tomography (CT) LCS. After curating a multimodal multitask dataset of 49 clinical data types, 163,725 chest CT series, and 17 tasks involved in LCS, we develop a scalable multimodal question-answering model architecture for synergistic multimodal multitasking. M3FM consistently outperforms the state-of-the-art models, improving lung cancer risk and cardiovascular disease mortality risk prediction by up to 20% and 10% respectively. M3FM processes multiscale high-dimensional images, handles various combinations of multimodal data, identifies informative data elements, and adapts to out-of-distribution tasks with minimal data. In this work, we show that M3FM advances various LCS tasks through large-scale multimodal and multitask learning.