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<p>Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous H<sub>2</sub>O<sub>2</sub> and O<sub>2</sub>. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBi<sup>V</sup>O<sub>3</sub>-PEG) can generate reactive oxygen species in an excitation-free and H<sub>2</sub>O<sub>2</sub>- and O<sub>2</sub>-independent manner. Upon exposure to the tumor microenvironment, NaBi<sup>V</sup>O<sub>3</sub>-PEG undergoes continuous H<sup>+</sup>-accelerated hydrolysis with •OH and <sup>1</sup>O<sub>2</sub> generation through electron transfer-mediated Bi<sup>V</sup>-to-Bi<sup>III</sup> conversion and lattice oxygen transformation. The simultaneous release of sodium counterions after endocytosis triggers caspase-1-mediated pyroptosis. NaBi<sup>V</sup>O<sub>3</sub>-PEG intratumorally administered initiates robust therapeutic efficacies against both primary and distant tumors and activates systemic immune responses to combat tumor metastasis. NaBi<sup>V</sup>O<sub>3</sub>-PEG intravenously administered can efficiently accumulate at the tumor site for further real-time computed tomography monitoring, immunotherapy, or alternative synergistic immune-radiotherapy. Overall, this work offers a nanomedicine based on high-valence bismuth(V) nanoplatform and underscores its great potential for cancer immunotherapy.</p>

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A high-valence bismuth(V) nanoplatform triggers cancer cell death and anti-tumor immune responses with exogenous excitation-free endogenous H2O2- and O2-independent ROS generation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月20日

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  • Yizhang Tang,
  • Xujiang Yu,
  • Liangrui He,
  • Meng Tang,
  • Wenji Yue,
  • Ruitong Chen,
  • Jie Zhao,
  • Qi Pan,
  • Wanwan Li

摘要

Reactive oxygen species with evoked immunotherapy holds tremendous promise for cancer treatment but has limitations due to its dependence on exogenous excitation and/or endogenous H2O2 and O2. Here we report a versatile oxidizing pentavalent bismuth(V) nanoplatform (NaBiVO3-PEG) can generate reactive oxygen species in an excitation-free and H2O2- and O2-independent manner. Upon exposure to the tumor microenvironment, NaBiVO3-PEG undergoes continuous H+-accelerated hydrolysis with •OH and 1O2 generation through electron transfer-mediated BiV-to-BiIII conversion and lattice oxygen transformation. The simultaneous release of sodium counterions after endocytosis triggers caspase-1-mediated pyroptosis. NaBiVO3-PEG intratumorally administered initiates robust therapeutic efficacies against both primary and distant tumors and activates systemic immune responses to combat tumor metastasis. NaBiVO3-PEG intravenously administered can efficiently accumulate at the tumor site for further real-time computed tomography monitoring, immunotherapy, or alternative synergistic immune-radiotherapy. Overall, this work offers a nanomedicine based on high-valence bismuth(V) nanoplatform and underscores its great potential for cancer immunotherapy.