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<p>During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.</p>

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Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月2日

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  • Leonhard Waschke,
  • Fabian Kamp,
  • Evi van den Elzen,
  • Suresh Krishna,
  • Ulman Lindenberger,
  • Ueli Rutishauser,
  • Douglas D. Garrett

摘要

During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.