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<p>A chemical reagent to access methyl sulfones has been developed. Its reaction with various <i>bis</i>-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF<sub>2</sub>-, CF<sub>3</sub>- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.</p>

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A reagent to access methyl sulfones

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年1月29日

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  • Yaroslav Poplavskyi,
  • Vasyl Ripenko,
  • Sergei Bova,
  • Angelina Biitseva,
  • Yurii V. Dmitriv,
  • Andrei A. Tolmachev,
  • Iryna V. Sadkova,
  • Iryna Pishel,
  • Oleksii Grygorov,
  • Vo Quang Huy Phan,
  • H. V. Rasika Dias,
  • Pavel K. Mykhailiuk

摘要

A chemical reagent to access methyl sulfones has been developed. Its reaction with various bis-nucleophiles leads to the rapid formation of previously unknown heteroaromatic methyl sulfones. Analogous strategy can also be used to construct alkyl-, CHF2-, CF3- and even bicyclo[1.1.1]pentane-containing derivatives. These compounds have been demonstrated to have a high potential for use in medicinal chemistry and coordination chemistry.