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<p>Premature ejaculation (PE) and erectile dysfunction (ED) commonly show a bidirectional association. Pharmacological treatments for PE often result in high dropout rates due to limited efficacy and adverse events. Penile prosthesis implantation (PPI) is considered a definitive treatment for ED. This study evaluated PPI’s safety and efficacy in improving ejaculatory and erectile function in patients with severe PE and refractory-to-medical-treatment ED. Seven patients with severe lifelong PE and ED unresponsive to medical therapies underwent three-piece inflatable PPI via an infrapubic approach. Functional outcomes were assessed at a six-month follow-up using the International Index of Erectile Function (IIEF), the Premature Ejaculation Diagnostic Tool (PEDT) and the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD). At 6 months, the self-estimated intravaginal ejaculation latency time (IELT) improved significantly (mean 726.4 sec vs. 40.7 sec, p &lt; 0.009; 95% CI: 1217.4; 153.9 sec), with reductions in PEDT scores (mean difference: −15.2, p &lt; 0.0001; 95% CI: −11.6; −18.8) and improvements in MSHQ-EjD scores (mean difference: 5.5, p &lt; 0.02). IIEF-EF scores increased by 14 points (p &lt; 0.001; 95%CI: 21.1; 6.8), with improvements in sexual desire, overall satisfaction, and intercourse satisfaction domains (all p &lt; 0.04). PPI significantly improved both ejaculatory and erectile outcomes in patients with severe PE and resistant-to-medical-therapy ED. Larger studies are needed to confirm these findings.</p>

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Penile prosthesis implantation for patients with comorbid severe premature ejaculation and erectile dysfunction: a pilot cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月11日

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  • Gabriele Antonini,
  • Sara Baldini,
  • Riccardo Terruzzi,
  • Piergiorgio Tuzzolo,
  • Paolo Capogrosso,
  • Alessio Villano,
  • Matteo Coschignano,
  • Ilaria Elena Zais,
  • Nicolò Schifano,
  • Antonio Aversa,
  • Federico Dehò

摘要

Premature ejaculation (PE) and erectile dysfunction (ED) commonly show a bidirectional association. Pharmacological treatments for PE often result in high dropout rates due to limited efficacy and adverse events. Penile prosthesis implantation (PPI) is considered a definitive treatment for ED. This study evaluated PPI’s safety and efficacy in improving ejaculatory and erectile function in patients with severe PE and refractory-to-medical-treatment ED. Seven patients with severe lifelong PE and ED unresponsive to medical therapies underwent three-piece inflatable PPI via an infrapubic approach. Functional outcomes were assessed at a six-month follow-up using the International Index of Erectile Function (IIEF), the Premature Ejaculation Diagnostic Tool (PEDT) and the Male Sexual Health Questionnaire for Ejaculatory Dysfunction (MSHQ-EjD). At 6 months, the self-estimated intravaginal ejaculation latency time (IELT) improved significantly (mean 726.4 sec vs. 40.7 sec, p < 0.009; 95% CI: 1217.4; 153.9 sec), with reductions in PEDT scores (mean difference: −15.2, p < 0.0001; 95% CI: −11.6; −18.8) and improvements in MSHQ-EjD scores (mean difference: 5.5, p < 0.02). IIEF-EF scores increased by 14 points (p < 0.001; 95%CI: 21.1; 6.8), with improvements in sexual desire, overall satisfaction, and intercourse satisfaction domains (all p < 0.04). PPI significantly improved both ejaculatory and erectile outcomes in patients with severe PE and resistant-to-medical-therapy ED. Larger studies are needed to confirm these findings.