Scholarlink

<p>Overactivation of sympathetic nervous system (SNS) has a key role in the pathophysiology of hypertension, as well as in chronic kidney disease, heart failure, atrial fibrillation, type 2 diabetes mellitus, obstructive sleep apnea, and anxiety disorders. Renal denervation (RDN) has been proven to lower blood pressure (BP) in hypertensive patients by reducing SNS activity. Beyond hypertension, data from a limited number of preclinical studies and clinical trials suggest that RDN may also be nephroprotective, have beneficial hemodynamic and clinical effects in patients with heart failure, reduce the burden of atrial fibrillation, have a moderate beneficial effect on glucose metabolism, and decrease the severity of obstructive sleep apnea. This study reviews the potential pleiotropic effects of RDN in these diseases that are characterized by SNS overactivation, and highlights the need for further well-designed, large-scale clinical trials to define the extent of these effects, clarify their clinical significance, and determine how they relate to RDN-induced changes in blood pressure.</p><p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Pleiotropic effects of renal denervation beyond blood pressure reduction

  • 期刊论文

  • 发表日期：

    2026年6月26日

查看全文
  • Angeliki Vakka,
  • Konstantinos G. Kyriakoulis,
  • Fotios Tatakis,
  • Panagiotis Iliakis,
  • Evangelia Kalliakouda,
  • Konstantia Papadomarkaki,
  • Aikaterini Damianaki,
  • Kyriakos Dimitriadis,
  • Dimitrios Konstantinidis,
  • Konstantinos Tsioufis

摘要

Overactivation of sympathetic nervous system (SNS) has a key role in the pathophysiology of hypertension, as well as in chronic kidney disease, heart failure, atrial fibrillation, type 2 diabetes mellitus, obstructive sleep apnea, and anxiety disorders. Renal denervation (RDN) has been proven to lower blood pressure (BP) in hypertensive patients by reducing SNS activity. Beyond hypertension, data from a limited number of preclinical studies and clinical trials suggest that RDN may also be nephroprotective, have beneficial hemodynamic and clinical effects in patients with heart failure, reduce the burden of atrial fibrillation, have a moderate beneficial effect on glucose metabolism, and decrease the severity of obstructive sleep apnea. This study reviews the potential pleiotropic effects of RDN in these diseases that are characterized by SNS overactivation, and highlights the need for further well-designed, large-scale clinical trials to define the extent of these effects, clarify their clinical significance, and determine how they relate to RDN-induced changes in blood pressure.