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<p>Although previous studies reported that BP PRS is associated with CVD, it is less explored whether BP PRS and BP are jointly associated with CVD, especially among non-European populations. Therefore, we examined joint associations of BP control and BP polygenic risk score (PRS) with CVD mortality in a Japanese population. Data were obtained from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, the multi-centered cohort study with 14 study areas throughout Japan. Of which, we analyzed ~35,000 Japanese individuals (Mean age: 55 years old, Men: 44%) with measured BP data (11,242 and 23,904 participants in subgroup #1 and #2). We developed PRS for systolic blood pressure (SBP) and diastolic blood pressure (DBP) in each subgroup. Participants were followed up from the baseline survey (2005–2014) to the end of 2020. Not elevated BP was defined as SBP ≤ 140 mmHg or DBP ≤ 90 mmHg regardless of antihypertensive medications. During the follow-up period, a total of 381 CVD deaths were observed. Compared with not elevated BP, HRs (95% CI) of CVD mortality were 1.98 (1.37–2.88) for elevated SBP and 2.41 (1.66–3.49) for elevated DBP. Compared to not elevated BP in the lowest PRS tertile, HRs (95% CI) of CVD mortality in the highest PRS tertile were 2.28 (1.17–4.43) for SBP and 3.08 (1.61–5.91) for DBP even though BP was not elevated. These associations in the subgroup #1 were replicated in the subgroup #2. Our findings highlighted the importance of BP PRS to detect a hidden CVD risk strata in addition to laboratory BP measurements.</p><p></p>

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Integration of polygenic risk score with measured blood pressure reveals hidden risks of cardiovascular disease mortality: A Japanese prospective cohort study

  • 期刊论文

  • 发表日期：

    2025年12月24日

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  • Hiroshi Okumiyama,
  • Ryosuke Fujii,
  • Mako Nagayoshi,
  • Masahiro Nakatochi,
  • Yoshiki Tsuboi,
  • Koji Suzuki,
  • Hiroaki Ikezaki,
  • Takuma Furukawa,
  • Rieko Okada,
  • Shiroh Tanoue,
  • Sadao Suzuki,
  • Teruhide Koyama,
  • Kiyonori Kuriki,
  • Naoyuki Takashima,
  • Takeshi Watanabe,
  • Asahi Hishida,
  • Yukihide Momozawa,
  • Mika Yageta Sakurai,
  • Atsushi Shimizu,
  • Kenji Wakai,
  • Keitaro Matsuo,
  • Nobuaki Michihata,
  • Hiroto Narimatsu,
  • Hidemi Ito,
  • Yoshikuni Kita,
  • Katsuyuki Miura,
  • Akihiro Ikezaki,
  • Keitaro Tanaka,
  • Chihaya Koriyama

摘要

Although previous studies reported that BP PRS is associated with CVD, it is less explored whether BP PRS and BP are jointly associated with CVD, especially among non-European populations. Therefore, we examined joint associations of BP control and BP polygenic risk score (PRS) with CVD mortality in a Japanese population. Data were obtained from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, the multi-centered cohort study with 14 study areas throughout Japan. Of which, we analyzed ~35,000 Japanese individuals (Mean age: 55 years old, Men: 44%) with measured BP data (11,242 and 23,904 participants in subgroup #1 and #2). We developed PRS for systolic blood pressure (SBP) and diastolic blood pressure (DBP) in each subgroup. Participants were followed up from the baseline survey (2005–2014) to the end of 2020. Not elevated BP was defined as SBP ≤ 140 mmHg or DBP ≤ 90 mmHg regardless of antihypertensive medications. During the follow-up period, a total of 381 CVD deaths were observed. Compared with not elevated BP, HRs (95% CI) of CVD mortality were 1.98 (1.37–2.88) for elevated SBP and 2.41 (1.66–3.49) for elevated DBP. Compared to not elevated BP in the lowest PRS tertile, HRs (95% CI) of CVD mortality in the highest PRS tertile were 2.28 (1.17–4.43) for SBP and 3.08 (1.61–5.91) for DBP even though BP was not elevated. These associations in the subgroup #1 were replicated in the subgroup #2. Our findings highlighted the importance of BP PRS to detect a hidden CVD risk strata in addition to laboratory BP measurements.