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<p>Fatty Liver Index (FLI) is associated with hypertension (HTN) in individuals undergoing general health screening and patients with hepatic steatosis; however, whether it is associated with HTN in patients undergoing coronary computed tomography angiography (CCTA) remains unclear. Therefore, to investigate this association, we conducted a cross-sectional study involving 1 173 patients with clinically suspected coronary artery disease. The primary outcomes of interest were FLI values and HTN prevalence. The mean FLI was 36.3 ± 25.8. Patients with HTN had a significantly higher FLI than those without HTN (39.1 ± 26.0 vs. 30.9 ± 24.7; <i>P</i> &lt; 0.001). FLI was divided into three value-based categories, lower, intermediate, and higher; the HTN prevalence among them was 59.2%, 69.0%, and 75.6%, respectively, showing a significant linear trend (<i>P</i> &lt; 0.001). A higher FLI was independently associated with HTN in a dose–response manner. Compared with the lower FLI group, the odds of HTN were greater in the intermediate (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.17–2.14, <i>P</i> = 0.003) and higher groups (OR: 2.59, 95% CI: 1.79–3.76, <i>P</i> &lt; 0.001). Results were consistent in a sensitivity model treating FLI as continuous, each 10–unit increase in FLI was associated with 15.6% higher odds of HTN (OR: 1.16, 95% CI: 1.10–1.22, <i>P</i> &lt; 0.001). Thus, FLI may serve as a valuable diagnostic indicator of HTN in patients undergoing CCTA, and incorporation of FLI assessment into routine CCTA evaluation protocols should be considered for more comprehensive cardiovascular risk assessment.</p><p></p>

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Association between hypertension and fatty liver index in patients undergoing coronary computed tomography angiography: a cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Tetsuo Hirata,
  • Yuhei Shiga,
  • Kohei Tashiro,
  • Sara Higashi,
  • Tetsuro Tachibana,
  • Yuto Kawahira,
  • Yasunori Suematsu,
  • Takashi Kuwano,
  • Makoto Sugihara,
  • Shin-ichiro Miura

摘要

Fatty Liver Index (FLI) is associated with hypertension (HTN) in individuals undergoing general health screening and patients with hepatic steatosis; however, whether it is associated with HTN in patients undergoing coronary computed tomography angiography (CCTA) remains unclear. Therefore, to investigate this association, we conducted a cross-sectional study involving 1 173 patients with clinically suspected coronary artery disease. The primary outcomes of interest were FLI values and HTN prevalence. The mean FLI was 36.3 ± 25.8. Patients with HTN had a significantly higher FLI than those without HTN (39.1 ± 26.0 vs. 30.9 ± 24.7; P < 0.001). FLI was divided into three value-based categories, lower, intermediate, and higher; the HTN prevalence among them was 59.2%, 69.0%, and 75.6%, respectively, showing a significant linear trend (P < 0.001). A higher FLI was independently associated with HTN in a dose–response manner. Compared with the lower FLI group, the odds of HTN were greater in the intermediate (odds ratio [OR]: 1.58, 95% confidence interval [CI]: 1.17–2.14, P = 0.003) and higher groups (OR: 2.59, 95% CI: 1.79–3.76, P < 0.001). Results were consistent in a sensitivity model treating FLI as continuous, each 10–unit increase in FLI was associated with 15.6% higher odds of HTN (OR: 1.16, 95% CI: 1.10–1.22, P < 0.001). Thus, FLI may serve as a valuable diagnostic indicator of HTN in patients undergoing CCTA, and incorporation of FLI assessment into routine CCTA evaluation protocols should be considered for more comprehensive cardiovascular risk assessment.