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<p>Vascular age (VA) as a surrogate of chronological age can improve cardiovascular risk prediction. This study examines which vascular age calculated by brachial-ankle pulse wave velocity (baPWV) or carotid-femoral pulse wave velocity (cfPWV) has a stronger association with the risk of cardiovascular events. This prospective study included 5723 participants from a community-based atherosclerosis cohort in Beijing, China. VA was defined as the predicted age in a multivariable regression model, including classical cardiovascular risk factors, treatment, and pulse wave velocity (baPWV or cfPWV). Residuals by regressing vascular age on chronological age were defined as ∆-age, and the 10th and 90th percentiles of ∆-age were used as cutoffs to define supernormal vascular aging, normal vascular aging, and early vascular aging, respectively. During the median 3.1-year follow-up period, 173 (3.0%) composite endpoints were observed. After adjusting for age and sex, ∆-age calculated by baPWV was significantly associated with cardiovascular risk (hazard ratio [HR]: 1.05, 95% confidence interval [CI]: 1.01–1.09, <i>p</i> = 0.025). After adjusting for traditional cardiovascular risk factors, early vascular aging group calculated by baPWV had an increased cardiovascular risk (HR: 1.84, 95% CI: 1.25–2.73, <i>p</i> = 0.002), compared with the normal vascular aging group. In contrast, no significant results were observed in the analyses of VA calculated by cfPWV. Since baPWV is a simple and convenient method, VA calculated by baPWV is more valuable for cardiovascular disease risk prediction of large sample population.</p><p></p>

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Comparison between vascular age based on brachial-ankle pulse wave velocity or carotid-femoral pulse wave velocity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Tianhui Dong,
  • Fangfang Fan,
  • Hongyu Chen,
  • Zhichen Dong,
  • Leyuan Yang,
  • Yiming Luo,
  • Zifeng Qiu,
  • Ran Fang,
  • Qiwen Zheng,
  • Xiangning Zhang,
  • Jianping Li,
  • Yong Huo,
  • Yan Zhang

摘要

Vascular age (VA) as a surrogate of chronological age can improve cardiovascular risk prediction. This study examines which vascular age calculated by brachial-ankle pulse wave velocity (baPWV) or carotid-femoral pulse wave velocity (cfPWV) has a stronger association with the risk of cardiovascular events. This prospective study included 5723 participants from a community-based atherosclerosis cohort in Beijing, China. VA was defined as the predicted age in a multivariable regression model, including classical cardiovascular risk factors, treatment, and pulse wave velocity (baPWV or cfPWV). Residuals by regressing vascular age on chronological age were defined as ∆-age, and the 10th and 90th percentiles of ∆-age were used as cutoffs to define supernormal vascular aging, normal vascular aging, and early vascular aging, respectively. During the median 3.1-year follow-up period, 173 (3.0%) composite endpoints were observed. After adjusting for age and sex, ∆-age calculated by baPWV was significantly associated with cardiovascular risk (hazard ratio [HR]: 1.05, 95% confidence interval [CI]: 1.01–1.09, p = 0.025). After adjusting for traditional cardiovascular risk factors, early vascular aging group calculated by baPWV had an increased cardiovascular risk (HR: 1.84, 95% CI: 1.25–2.73, p = 0.002), compared with the normal vascular aging group. In contrast, no significant results were observed in the analyses of VA calculated by cfPWV. Since baPWV is a simple and convenient method, VA calculated by baPWV is more valuable for cardiovascular disease risk prediction of large sample population.