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<p>The correlation between lipoprotein cholesterol levels and hematoma expansion (HE) following intracerebral hemorrhage (ICH) remains unknown. We aimed to elucidate the correlation between high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and HE following acute ICH in entire ICH, non-lobar ICH, and lobar ICH cohorts. Consecutive patients with ICH between July 2012 and November 2023 were screened. The inclusion criteria were: (1) onset to door time within 24 h; (2) availability of serum HDL-C and LDL-C level evaluations on admission; and (3) availability of HE evaluation. We investigated the association between HDL-C and LDL-C levels and HE using Poisson regression analyses with a robust variance estimator in three models with adjustment for various factors. Screening of 608 consecutive ICH patients revealed 409 with acute ICH (204 [50%] males, median age 75 years). HE was observed in 43 patients (11%). In the entire ICH cohort, lower HDL-C was independently associated with HE in all the study models (<i>p</i> &lt; 0.05). Further, a negative linear association was observed between HDL-C quartiles and HE in reference to HDL-C Quartile 4 in all the models (<i>p</i> &lt; 0.05 for trend). These significant associations were also observed in the non-lobar ICH cohort, but not in the lobar ICH cohort. LDL-C was not associated with HE in any of the cohorts. In acute ICH patients, lower HDL-C was associated with HE, especially in the non-lobar ICH cohort generally caused by hypertensive microangiopathy. HDL-C might have protective potential against HE following ICH.</p><p></p>

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Lower high-density lipoprotein cholesterol level is associated with hematoma expansion in acute intracerebral hemorrhage: association with hypertensive microangiopathy

  • 期刊论文

  • 发表日期：

    2025年7月7日

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  • Takeo Sato,
  • Yuka Tsuchimochi,
  • Yuki Hamada,
  • Kaishi Kukihara,
  • Yutaro Kawabata,
  • Kana Iwamoto,
  • Go Takaguchi,
  • Yujiro Higuchi,
  • Hideki Matsuoka,
  • Hiroshi Takashima

摘要

The correlation between lipoprotein cholesterol levels and hematoma expansion (HE) following intracerebral hemorrhage (ICH) remains unknown. We aimed to elucidate the correlation between high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels and HE following acute ICH in entire ICH, non-lobar ICH, and lobar ICH cohorts. Consecutive patients with ICH between July 2012 and November 2023 were screened. The inclusion criteria were: (1) onset to door time within 24 h; (2) availability of serum HDL-C and LDL-C level evaluations on admission; and (3) availability of HE evaluation. We investigated the association between HDL-C and LDL-C levels and HE using Poisson regression analyses with a robust variance estimator in three models with adjustment for various factors. Screening of 608 consecutive ICH patients revealed 409 with acute ICH (204 [50%] males, median age 75 years). HE was observed in 43 patients (11%). In the entire ICH cohort, lower HDL-C was independently associated with HE in all the study models (p < 0.05). Further, a negative linear association was observed between HDL-C quartiles and HE in reference to HDL-C Quartile 4 in all the models (p < 0.05 for trend). These significant associations were also observed in the non-lobar ICH cohort, but not in the lobar ICH cohort. LDL-C was not associated with HE in any of the cohorts. In acute ICH patients, lower HDL-C was associated with HE, especially in the non-lobar ICH cohort generally caused by hypertensive microangiopathy. HDL-C might have protective potential against HE following ICH.