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Background/objectives <p>To assess the effect of intracameral moxifloxacin (ICM) after repaired open globe injury (OGI) in reducing the incidence of post-traumatic endophthalmitis.</p> Subjects/methods <p>Ambispective, consecutive, comparative study of patients operated of OGI repair. Patients were divided into two groups: those without intracameral antibiotic prophylaxis (No-ICM) (operated between 2002 and 2012) and those with ICM prophylaxis at the end of the procedure (ICM) (operated between 2013 and 2023). Both received standard povidone-iodine antisepsis. Endophthalmitis was defined as severe intraocular inflammation associated with hypopyon and/or vitritis.</p> Results <p>424 eyes (424 patients) were included, 294 in ICM group and 130 in No-ICM group. Male sex was 85.7% and 90.8% in ICM and No-ICM groups, respectively. The ICM group was significantly older than No-ICM group (median (IQR): 26 (14–41) vs. 21.5 (12–34), <i>p</i> = 0.025). The proportion of patients younger than 18 years was similar between ICM and No-ICM group (33.1% vs. 38.5%, <i>p</i> = 0.275). Post-traumatic endophthalmitis was significantly lower in ICM (2/294, 0.7%) compared to No-ICM (5/130, 3.9%) (<i>p</i> = 0.031) group. Sensitivity analysis age-adjusted confirmed the protective effect of ICM for endophthalmitis after OGI was independent of age (adjusted OR: 0.20; 95% CI: 0.04–0.86; <i>p</i> = 0.031). The relative risk of endophthalmitis with ICM compared with no-ICM was 0.18 (0.04–0.78), with relative risk reduction of 82%, absolute risk reduction of 3.2%, and a number needed to treat of 32 to prevent one case of endophthalmitis following OGI repair.</p> Conclusions <p>ICM at the end of surgery reduces the incidence of post-traumatic endophthalmitis after OGI repair, compared with no intracameral antibiotic prophylaxis.</p>

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Incidence of post-traumatic endophthalmitis following repaired open globe injury: impact of prophylactic intracameral moxifloxacin

  • 期刊论文

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  • 发表日期：

    2026年2月26日

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  • Karim Mohamed-Noriega,
  • Alicia J. Hernández-Moreno,
  • Fernando Morales-Wong,
  • Jibran Mohamed-Noriega,
  • Jesús H. González-Cortés,
  • Gerardo Villarreal-Mendez,
  • Jesús Mohamed-Hamsho

摘要

Background/objectives

To assess the effect of intracameral moxifloxacin (ICM) after repaired open globe injury (OGI) in reducing the incidence of post-traumatic endophthalmitis.

Subjects/methods

Ambispective, consecutive, comparative study of patients operated of OGI repair. Patients were divided into two groups: those without intracameral antibiotic prophylaxis (No-ICM) (operated between 2002 and 2012) and those with ICM prophylaxis at the end of the procedure (ICM) (operated between 2013 and 2023). Both received standard povidone-iodine antisepsis. Endophthalmitis was defined as severe intraocular inflammation associated with hypopyon and/or vitritis.

Results

424 eyes (424 patients) were included, 294 in ICM group and 130 in No-ICM group. Male sex was 85.7% and 90.8% in ICM and No-ICM groups, respectively. The ICM group was significantly older than No-ICM group (median (IQR): 26 (14–41) vs. 21.5 (12–34), p = 0.025). The proportion of patients younger than 18 years was similar between ICM and No-ICM group (33.1% vs. 38.5%, p = 0.275). Post-traumatic endophthalmitis was significantly lower in ICM (2/294, 0.7%) compared to No-ICM (5/130, 3.9%) (p = 0.031) group. Sensitivity analysis age-adjusted confirmed the protective effect of ICM for endophthalmitis after OGI was independent of age (adjusted OR: 0.20; 95% CI: 0.04–0.86; p = 0.031). The relative risk of endophthalmitis with ICM compared with no-ICM was 0.18 (0.04–0.78), with relative risk reduction of 82%, absolute risk reduction of 3.2%, and a number needed to treat of 32 to prevent one case of endophthalmitis following OGI repair.

Conclusions

ICM at the end of surgery reduces the incidence of post-traumatic endophthalmitis after OGI repair, compared with no intracameral antibiotic prophylaxis.