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Purpose <p>To assess relationship between dark without pressure (DWP) retinopathy and retinal vasculitis (RV) in paediatric uveitis patients.</p> Methods <p>This is a retrospective cross-sectional study. Wide angle fundus photographs (WAFP), fundus autofluorescence (FAF), and optical coherence tomography (OCT) images were analysed to identify DWP retinopathy. Confluent dark areas on WAFP, hypo-autofluorescence on FAF, and EZ disruption on OCT images were the markers for DWP. DWP retinopathy area was measured using Image-J. The prevalence and characteristics of DWP in RV patients and its association with RV was reported.</p> Results <p>Out of 43 paediatric uveitis patients, 26 were diagnosed with RV. Amongst these, DWP was detected in 20 patients (30 eyes) which were analysed. Mean age was 12.8 ± 3.36 years; 40% were female. DWP areas were either diffuse, mid-peripheral or peripheral on WAFP. All 20 patients (30 eyes) showed hypo-autofluorescence on FAF at the same locations as the WAFP. The mean duration of follow-up was 27.2 ( ± 13.7) months. 12 patients (19 eyes) who had DWP at baseline visit had longer duration of uveitis compared to 8 patients (11 eyes) who developed DWP on follow-up visits (<i>p</i> &lt; 0.036). Progression of the retinopathy overtime was analysed in 28 eyes; all eyes showed improvement of RV with therapy. There was a statistically significant relationship between change in vascular leakage and the change in DWP retinopathy area (chi square= 11.67, <i>p</i> = 0.001).</p> Conclusions <p>DWP can potentially serve as a biomarker of RV in paediatric uveitis patients and its presence should warrant WAFA evaluation in this patient population.</p>

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Multimodal imaging of dark without pressure lesions in paediatric retinal vasculitis: A cross-sectional study

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • Cigdem Yasar,
  • Muhammad Hassan,
  • Hashem Ghoraba,
  • Christopher Or,
  • Amir Akhavanrezayat,
  • Jonathan Regenold,
  • Sungwho Park,
  • Hassan Khojasteh,
  • Muhammad Sohail Halim,
  • Irmak Karaca,
  • Brandon Huy Pham,
  • Gunay Uludag,
  • Wataru Matsumiya,
  • Quan Dong Nguyen

摘要

Purpose

To assess relationship between dark without pressure (DWP) retinopathy and retinal vasculitis (RV) in paediatric uveitis patients.

Methods

This is a retrospective cross-sectional study. Wide angle fundus photographs (WAFP), fundus autofluorescence (FAF), and optical coherence tomography (OCT) images were analysed to identify DWP retinopathy. Confluent dark areas on WAFP, hypo-autofluorescence on FAF, and EZ disruption on OCT images were the markers for DWP. DWP retinopathy area was measured using Image-J. The prevalence and characteristics of DWP in RV patients and its association with RV was reported.

Results

Out of 43 paediatric uveitis patients, 26 were diagnosed with RV. Amongst these, DWP was detected in 20 patients (30 eyes) which were analysed. Mean age was 12.8 ± 3.36 years; 40% were female. DWP areas were either diffuse, mid-peripheral or peripheral on WAFP. All 20 patients (30 eyes) showed hypo-autofluorescence on FAF at the same locations as the WAFP. The mean duration of follow-up was 27.2 ( ± 13.7) months. 12 patients (19 eyes) who had DWP at baseline visit had longer duration of uveitis compared to 8 patients (11 eyes) who developed DWP on follow-up visits (p < 0.036). Progression of the retinopathy overtime was analysed in 28 eyes; all eyes showed improvement of RV with therapy. There was a statistically significant relationship between change in vascular leakage and the change in DWP retinopathy area (chi square= 11.67, p = 0.001).

Conclusions

DWP can potentially serve as a biomarker of RV in paediatric uveitis patients and its presence should warrant WAFA evaluation in this patient population.