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Aims <p>This study aimed to examine the impact of laser peripheral iridotomy (LPI) on subgroups of primary angle closure eyes based on swept-source optical coherence tomography (SS-OCT).</p> Methods <p>SS-OCT was used to image 115 eyes with primary angle-closure disease (PACD) at prior to LPI, 1 week, 4 weeks and 12 weeks after LPI. A hierarchical cluster analysis was conducted to classify PACD eyes into subgroups based on pre-LPI SS-OCT parameters. The primary parameters were then compared after LPI to assess any variations in the outcomes among the identified subgroups. A mixed-effects model was used to evaluate the difference between subgroups and the effect of LPI.</p> Results <p>The hierarchical cluster analysis resulted in the identification of two distinct clusters. Cluster 1 (56 eyes) exhibited larger lens vault, pupil distance, iris volume, iris area, iris thickness 2000, as well as narrower angles (<i>p</i> &lt; 0.05 for all). Cluster 2 (59 eyes) had smaller anterior chamber width and anterior chamber volume (<i>p</i> &lt; 0.05 for all). Following LPI, there was an observed increase in the angle size and a decrease in irido-trabecular contact index (ITCI) in both clusters (<i>p</i> &lt; 0.05 for all). Over a period of 3 months, the cluster 1 exhibited stability in angle size and ITCI, whereas cluster 2 exhibited a gradual decline in angle size and a gradual increase in ITCI (<i>p</i> &lt; 0.05 for all).</p> Conclusion <p>This study successfully identified two distinct subgroups of PACD eyes based on SS-OCT parameters. Smaller eyes demonstrated a declining response to LPI over a period of 3 months.</p>

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Outcomes of laser peripheral iridotomy in subgroups of primary angle closure disease eyes according to swept-source optical coherence tomography parameters

  • 期刊论文

  • 发表日期：

    2025年4月17日

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  • Le-Feng Wang,
  • Hao-Tian Xiang,
  • Si-Jie Chen,
  • Shan-Ming Jiang,
  • Jia-Ying Zhang,
  • Xue-Lin Tang,
  • Hong Lin,
  • Ni Li

摘要

Aims

This study aimed to examine the impact of laser peripheral iridotomy (LPI) on subgroups of primary angle closure eyes based on swept-source optical coherence tomography (SS-OCT).

Methods

SS-OCT was used to image 115 eyes with primary angle-closure disease (PACD) at prior to LPI, 1 week, 4 weeks and 12 weeks after LPI. A hierarchical cluster analysis was conducted to classify PACD eyes into subgroups based on pre-LPI SS-OCT parameters. The primary parameters were then compared after LPI to assess any variations in the outcomes among the identified subgroups. A mixed-effects model was used to evaluate the difference between subgroups and the effect of LPI.

Results

The hierarchical cluster analysis resulted in the identification of two distinct clusters. Cluster 1 (56 eyes) exhibited larger lens vault, pupil distance, iris volume, iris area, iris thickness 2000, as well as narrower angles (p < 0.05 for all). Cluster 2 (59 eyes) had smaller anterior chamber width and anterior chamber volume (p < 0.05 for all). Following LPI, there was an observed increase in the angle size and a decrease in irido-trabecular contact index (ITCI) in both clusters (p < 0.05 for all). Over a period of 3 months, the cluster 1 exhibited stability in angle size and ITCI, whereas cluster 2 exhibited a gradual decline in angle size and a gradual increase in ITCI (p < 0.05 for all).

Conclusion

This study successfully identified two distinct subgroups of PACD eyes based on SS-OCT parameters. Smaller eyes demonstrated a declining response to LPI over a period of 3 months.