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Background <p>Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of <i>CYP2R1</i>/<i>GC</i> gene polymorphisms on vitamin D<sub>3</sub> supplementation responsiveness in prediabetes.</p> Methods <p>A total of 240 prediabetic participants received orally 1600 IU of vitamin D<sub>3</sub> or placebo daily for 24 weeks.</p> Results <p><i>CYP2R1</i> rs12794714 AA carriers had less increased 25(OH)D<sub>3</sub> levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), <i>P</i> = 0.038). Moreover, <i>GC</i> rs4588 GA carriers had less increased 25(OH)D<sub>3</sub> levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), <i>P</i> = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), <i>P</i> = 0.032). <i>GC</i> rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), <i>P</i> = 0.042).</p> Conclusions <p>The results indicated that <i>CYP2R1</i> rs12794714, <i>GC</i> rs4588, and <i>GC</i> rs4752 polymorphism were associated with vitamin D<sub>3</sub> supplementation responsiveness in prediabetes.</p>

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Effect of CYP2R1 and GC gene polymorphisms on serum 25(OH)D response to vitamin D3 supplementation in prediabetes

  • 期刊论文

  • 发表日期：

    2025年3月20日

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  • Peng Ni,
  • Ze Xu,
  • Yujing Zhang,
  • Dongdong Zhang,
  • Hongwei Wen,
  • Yaping Liu,
  • Wenjie Li,
  • Xing Li

摘要

Background

Prediabetes is a crucial period for preventing and managing diabetes. This study aimed to explore the effects of CYP2R1/GC gene polymorphisms on vitamin D3 supplementation responsiveness in prediabetes.

Methods

A total of 240 prediabetic participants received orally 1600 IU of vitamin D3 or placebo daily for 24 weeks.

Results

CYP2R1 rs12794714 AA carriers had less increased 25(OH)D3 levels compared with GG carriers after supplementation (3.42 (0.05, 6.79) vs. 8.49 (6.14, 10.83), P = 0.038). Moreover, GC rs4588 GA carriers had less increased 25(OH)D3 levels compared with GG carriers (4.71 (2.64, 6.79) vs. 8.17 (6.37, 9.98), P = 0.033); it also had lower supplementation responsiveness (0.35 (0.14, 0.91), P = 0.032). GC rs4752 AG carriers had higher supplementation responsiveness compared with AA carriers (3.48 (1.05, 11.59), P = 0.042).

Conclusions

The results indicated that CYP2R1 rs12794714, GC rs4588, and GC rs4752 polymorphism were associated with vitamin D3 supplementation responsiveness in prediabetes.