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Objectives <p>This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.</p> Methods <p>This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.</p> Results <p>The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0–63.0), 66.4% (<i>n</i> = 481) male. Most patients had alcoholic cirrhosis (<i>n</i> = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged &lt;60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.</p> Conclusion <p>These cutoff points could be used to identify patients with a higher mortality risk.</p> <p></p>

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Cutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study

  • 期刊论文

  • 发表日期：

    2025年1月14日

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  • Bárbara Chaves Santos,
  • Bruna Cherubini Alves,
  • Ana Luisa Ferreira Fonseca,
  • Samanta Catherine Ferreira,
  • Yani Gláucia Gomide Mizubuti,
  • Camila Saueressig,
  • Ramona Souza da Silva Baqueiro Boulhosa,
  • Lívia Alves Amaral Santos,
  • Carla de Magalhães Cunha,
  • Andre Castro Lyra,
  • Lucivalda Pereira Magalhães Oliveira,
  • Rosângela Passos de Jesus,
  • Fernando Gomes Romeiro,
  • Valesca Dall’Alba,
  • Vivian Cristine Luft,
  • Maria Isabel Toulson Davisson Correia,
  • Lívia Garcia Ferreira,
  • Lucilene Rezende Anastácio

摘要

Objectives

This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis.

Methods

This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS.

Results

The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0–63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality.

Conclusion

These cutoff points could be used to identify patients with a higher mortality risk.