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<p>Two new 2-benzylfuran compounds, designated as paramyfurans A (<b>1</b>) and B (<b>2</b>), and a new dihydrocoumarin compound, designated as paramylactone (<b>3</b>), along with abscisic acid (<b>4</b>), were isolated from the culture broth of the fungal strain <i>Paramyrothecium</i> sp. BF-1049. The planar structures of <b>1</b>, <b>2</b>, and <b>3</b> were elucidated based on spectroscopic analyses, including 1D and 2D NMR. Compound <b>3</b> was further separated into its enantiomers, namely (+)-paramylactone ((+)-<b>3</b>) and (−)-paramylactone ((−)-<b>3</b>), by HPLC using a chiral column. Their absolute stereochemistry was determined by comparing calculated and experimental ECD spectra. Compounds <b>1</b>–<b>4</b> exhibited cytotoxic activity against three mesothelioma cell lines (NCI-H2452, NCI-H2052, and Y-MESO-27), with IC<sub>50</sub> values ranging from 0.68 to 19.86 μM.</p>

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New anti-mesothelioma compounds, paramyfurans and paramylactone, produced by Paramyrothecium sp. BF-1049

  • 期刊论文

  • 发表日期：

    2026年5月19日

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  • Satoshi Ohte,
  • Kana Sakaguchi,
  • Yasuomi Kiyota,
  • Tatsuhiro Sato,
  • Mayuko Takeda-Shitaka,
  • Hiroshi Tomoda,
  • Taichi Ohshiro

摘要

Two new 2-benzylfuran compounds, designated as paramyfurans A (1) and B (2), and a new dihydrocoumarin compound, designated as paramylactone (3), along with abscisic acid (4), were isolated from the culture broth of the fungal strain Paramyrothecium sp. BF-1049. The planar structures of 1, 2, and 3 were elucidated based on spectroscopic analyses, including 1D and 2D NMR. Compound 3 was further separated into its enantiomers, namely (+)-paramylactone ((+)-3) and (−)-paramylactone ((−)-3), by HPLC using a chiral column. Their absolute stereochemistry was determined by comparing calculated and experimental ECD spectra. Compounds 1–4 exhibited cytotoxic activity against three mesothelioma cell lines (NCI-H2452, NCI-H2052, and Y-MESO-27), with IC50 values ranging from 0.68 to 19.86 μM.