Scholarlink

<p><i>Neisseria gonorrhoeae</i> is the bacterium that causes gonorrhea, and multidrug resistance is becoming progressively more severe in many countries. Therefore, limited drugs are available for treatment. It is predicted that further drug resistance will be acquired, making treatment still more difficult, so there is an urgent need to develop new drugs. We discovered three compounds with a new kalafungin-type pyranonaphthoquinone skeleton, thiofrenomycins A-C, that exhibit strong antibacterial activity against <i>N. gonorrhoeae</i> in a culture solution of <i>Streptomyces</i> sp. MM863L-181F9 derived from fallen leaves. The absolute stereochemistry of these compounds was determined using X-ray crystal structure analysis. These substances exhibit minimal inhibitory concentrations of 0.125–16 µg/mL against <i>N. gonorrhoeae</i>.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Thiofrenomycins, new kalafungin-type pyranonaphthoquinone skeleton with sulfide linkage from Streptomyces sp. MM863L-181F9

  • 期刊论文

  • 发表日期：

    2025年11月21日

查看全文
  • Tomoyuki Kimura,
  • Yoshimasa Ishizaki,
  • Maya Umekita,
  • Rie Arisaka,
  • Hideyuki Muramatsu,
  • Chigusa Hayashi,
  • Isao Momose,
  • Ken Shimuta,
  • Ryuichi Sawa,
  • Masayuki Igarashi

摘要

Neisseria gonorrhoeae is the bacterium that causes gonorrhea, and multidrug resistance is becoming progressively more severe in many countries. Therefore, limited drugs are available for treatment. It is predicted that further drug resistance will be acquired, making treatment still more difficult, so there is an urgent need to develop new drugs. We discovered three compounds with a new kalafungin-type pyranonaphthoquinone skeleton, thiofrenomycins A-C, that exhibit strong antibacterial activity against N. gonorrhoeae in a culture solution of Streptomyces sp. MM863L-181F9 derived from fallen leaves. The absolute stereochemistry of these compounds was determined using X-ray crystal structure analysis. These substances exhibit minimal inhibitory concentrations of 0.125–16 µg/mL against N. gonorrhoeae.