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<p>Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant <i>Streptococcus pneumoniae</i>. The study confirms that LSFX’s elevated concentration in ELF plays a significant role in its bactericidal activity.</p>

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Evaluation of lung epithelial lining fluid concentrations of lascufloxacin against Streptococcus pneumoniae in a hollow-fiber infection model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月7日

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  • Haruka Nakagawa Kamura,
  • Tetsuo Yamaguchi,
  • Toshihiro Kasama,
  • Yukitaka Hayashi,
  • Masakaze Hamada,
  • Kazuaki Matsumoto,
  • Ryo Miyake,
  • Yoshikazu Ishii

摘要

Lascufloxacin (LSFX) achieves concentrations in epithelial lining fluid (ELF) that are more than 15 times higher than those in the bloodstream, making it a promising candidate for respiratory and otorhinolaryngological infections. These concentrations were replicated using the Hollow-Fiber Infection Model and demonstrated bactericidal efficacy of LSFX against levofloxacin-sensitive and -resistant Streptococcus pneumoniae. The study confirms that LSFX’s elevated concentration in ELF plays a significant role in its bactericidal activity.