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<p>Three new compounds including two thiodiketopiperazine derivatives shovelmycins A–B (<b>1</b>–<b>2</b>), and one ansamycin derivative divergolide X (<b>3</b>) were isolated and identified from the culture extract of <i>Streptomyces olivaceus</i> HDN22-001, a marine actinomycete obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses and ECD calculations. Compound <b>1</b> exhibited the strongest DPPH radical scavenging activity with an IC<sub>50</sub> value of 10.83 μM, which was better than that of the positive control vitamin C. And compound <b>2</b> was modestly cytotoxic against NCl-H446 cell with the IC<sub>50</sub> value of 26.6 μM.</p>

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The thiodiketopiperazine derivatives shovelmycin A–B and ansamycin derivative divergolide X from the cold-seep-derived Streptomyces olivaceus HDN22-001

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Chen Li,
  • Jiangli Cheng,
  • Ruojin Liu,
  • Xiaofei Huang,
  • Luning Zhou,
  • Guojian Zhang,
  • Tianjiao Zhu,
  • Dehai Li,
  • Qian Che

摘要

Three new compounds including two thiodiketopiperazine derivatives shovelmycins A–B (1–2), and one ansamycin derivative divergolide X (3) were isolated and identified from the culture extract of Streptomyces olivaceus HDN22-001, a marine actinomycete obtained from the deep-sea cold seep sediment sample collected from the South China Sea. Their structures and absolute configurations were determined by spectroscopic analyses and ECD calculations. Compound 1 exhibited the strongest DPPH radical scavenging activity with an IC50 value of 10.83 μM, which was better than that of the positive control vitamin C. And compound 2 was modestly cytotoxic against NCl-H446 cell with the IC50 value of 26.6 μM.