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<p>Two new benzene-containing polyketides, cryptoic acids A (<b>1</b>) and B (<b>2</b>), along with a new acylated diketopiperazine designated cyclocryptamide (<b>3</b>), were isolated from the culture extract of <i>Cryptosporangium</i> sp. YDKA-T02. The absolute configuration of amino acid components in <b>3</b> was determined by Marfey’s method. While <b>3</b> was not cytotoxic and inactive against microbial test strains, <b>1</b> and <b>2</b> showed PPARγ agonistic activity in a reporter gene assay and cytotoxicity against P388 murine leukemia cells.</p>

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Cryptoic acids A and B, benzene-containing polyketides, and cyclocryptamide, a modified diketopiperazine, from an actinomycete of the genus Cryptosporangium

  • 期刊论文

  • 发表日期：

    2025年1月6日

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  • Md. Julkar Nime,
  • Hideki Yamamura,
  • Masayuki Hayakawa,
  • Nobuyasu Matsuura,
  • Naoya Oku,
  • Yasuhiro Igarashi

摘要

Two new benzene-containing polyketides, cryptoic acids A (1) and B (2), along with a new acylated diketopiperazine designated cyclocryptamide (3), were isolated from the culture extract of Cryptosporangium sp. YDKA-T02. The absolute configuration of amino acid components in 3 was determined by Marfey’s method. While 3 was not cytotoxic and inactive against microbial test strains, 1 and 2 showed PPARγ agonistic activity in a reporter gene assay and cytotoxicity against P388 murine leukemia cells.