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<p>In this study, a highly viscoelastic, deformable, and adhesive hydrogel was synthesized by crosslinking a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer hydrogel with a chemical crosslinker [<i>N</i>,<i>N</i>′-methylenebisacrylamide (MB)] using a cationic initiator, 2,2′-azobis-[2-(1,3-dimethyl-4,5-dihydro-1<i>H</i>-imidazol-3-ium-2-yl)]propane triflate (ADIP). The adhesive PMPC gel was tolerant to peeling during adhesion, and the adhesion energy of the hydrogel increased as the contact time with the adhesion target increased. Furthermore, the mechanism underlying the synthesis of deformable and adhesive hydrogels was determined by analyzing the polymerization behavior. The polymer synthesized with ADIP had a lower molecular weight than that synthesized with a conventional redox-type initiator, ammonium persulfate/<i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetramethylethylenediamine. Moreover, an analysis of the reactivity of various monomers and crosslinkers indicated low reactivity of the acrylamide-type crosslinker MB to methacrylate-type monomers; on this basis, the appropriate combination of monomers and crosslinkers for generating the target hydrogel was determined. The cytocompatibility of the prepared PMPC hydrogel was also confirmed. Thus, this study provides guidelines for the rational design of highly deformable, adhesive hydrogels with cytocompatibility.</p>

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Development of deformable and adhesive biocompatible polymer hydrogels by a simple one-pot method using ADIP as a cationic radical initiator

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月27日

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  • Tsukuru Masuda,
  • Yui Saegusa,
  • Toshikazu Tsuji,
  • Madoka Takai

摘要

In this study, a highly viscoelastic, deformable, and adhesive hydrogel was synthesized by crosslinking a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer hydrogel with a chemical crosslinker [N,N′-methylenebisacrylamide (MB)] using a cationic initiator, 2,2′-azobis-[2-(1,3-dimethyl-4,5-dihydro-1H-imidazol-3-ium-2-yl)]propane triflate (ADIP). The adhesive PMPC gel was tolerant to peeling during adhesion, and the adhesion energy of the hydrogel increased as the contact time with the adhesion target increased. Furthermore, the mechanism underlying the synthesis of deformable and adhesive hydrogels was determined by analyzing the polymerization behavior. The polymer synthesized with ADIP had a lower molecular weight than that synthesized with a conventional redox-type initiator, ammonium persulfate/N,N,N′,N′-tetramethylethylenediamine. Moreover, an analysis of the reactivity of various monomers and crosslinkers indicated low reactivity of the acrylamide-type crosslinker MB to methacrylate-type monomers; on this basis, the appropriate combination of monomers and crosslinkers for generating the target hydrogel was determined. The cytocompatibility of the prepared PMPC hydrogel was also confirmed. Thus, this study provides guidelines for the rational design of highly deformable, adhesive hydrogels with cytocompatibility.