Scholarlink

<p>The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIP<sub>n</sub>) signaling is a critical regulator of these processes and other biological activities, though its precise impact on cytoskeletal dynamics has yet to be systematically investigated. This review explores the complex interplay between PIP<sub>n</sub> signaling and the cytoskeleton, detailing how PIP<sub>n</sub> modulates the dynamics of actin, intermediate filaments, and microtubules to shape cellular behavior. Dysregulation of PIP<sub>n</sub> signaling is implicated in various diseases, including cancer, highlighting promising therapeutic opportunities through targeted modulation of these pathways. Future research should aim to elucidate the intricate molecular interactions and broader cellular responses to PIP<sub>n</sub> signaling perturbations, particularly in disease contexts, to devise effective strategies for restoring cytoskeletal integrity.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phosphoinositide signaling at the cytoskeleton in the regulation of cell dynamics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月14日

查看全文
  • Xiaoting Hou,
  • Yu Chen,
  • Noah D. Carrillo,
  • Vincent L. Cryns,
  • Richard A. Anderson,
  • Jichao Sun,
  • Songlin Wang,
  • Mo Chen

摘要

The cytoskeleton, composed of microfilaments, intermediate filaments, and microtubules, provides the structural basis for cellular functions such as motility and adhesion. Equally crucial, phosphoinositide (PIPn) signaling is a critical regulator of these processes and other biological activities, though its precise impact on cytoskeletal dynamics has yet to be systematically investigated. This review explores the complex interplay between PIPn signaling and the cytoskeleton, detailing how PIPn modulates the dynamics of actin, intermediate filaments, and microtubules to shape cellular behavior. Dysregulation of PIPn signaling is implicated in various diseases, including cancer, highlighting promising therapeutic opportunities through targeted modulation of these pathways. Future research should aim to elucidate the intricate molecular interactions and broader cellular responses to PIPn signaling perturbations, particularly in disease contexts, to devise effective strategies for restoring cytoskeletal integrity.