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Background <p>Limited knowledge exists on the association between hospital contacts before a childhood cancer diagnosis and the risk of early mortality.</p> Methods <p>We conducted a register-based cohort study including 14,089 children with cancer diagnosed in 1989 − 2014 in Denmark and Sweden. Odds ratios (ORs) and 95% confidence intervals (CIs) of early mortality (deaths within 0-90 days) were estimated by nights in hospital up to two years prior cancer diagnosis and diagnoses within specific main diagnostic categories using logistic regression.</p> Results <p>Children hospitalized ≥14 nights within 2 years−14 days and 3 months−14 days before cancer diagnosis faced elevated ORs of early mortality (4.6, 95% CI 3.2–6.4; 4.4, 2.9–6.7). The association was not explained by maternal education. Early mortality was associated with diagnoses within several diagnostic categories prior to cancer diagnosis, including infectious (OR 1.5, 95% CI 1.1–2.0) and endocrine diseases (OR 1.6, 95% CI 1.02–2.5), blood (OR 3.3, 95% CI 2.1–5.1) and digestive disorders (OR 1.9, 95% CI 1.4–2.6), and symptoms with no specific diagnosis (OR 1.4, 95% CI 1.1–8).</p> Conclusion <p>Children with increased time in hospital before cancer diagnosis had a higher risk for early mortality, which indicates underlying health vulnerabilities or pre-existing fragility in this population.</p>

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Hospital contacts before childhood cancer and the risk of early mortality: a Danish and Swedish population-based cohort study

  • 期刊论文

  • 发表日期：

    2026年7月23日

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  • Line Kenborg,
  • Hanna Mogensen,
  • Henrik Hasle,
  • Thomas T. Nielsen,
  • Mats Talbäck,
  • Maria Feychting,
  • Friederike Erdmann,
  • Giorgio Tettamanti

摘要

Background

Limited knowledge exists on the association between hospital contacts before a childhood cancer diagnosis and the risk of early mortality.

Methods

We conducted a register-based cohort study including 14,089 children with cancer diagnosed in 1989 − 2014 in Denmark and Sweden. Odds ratios (ORs) and 95% confidence intervals (CIs) of early mortality (deaths within 0-90 days) were estimated by nights in hospital up to two years prior cancer diagnosis and diagnoses within specific main diagnostic categories using logistic regression.

Results

Children hospitalized ≥14 nights within 2 years−14 days and 3 months−14 days before cancer diagnosis faced elevated ORs of early mortality (4.6, 95% CI 3.2–6.4; 4.4, 2.9–6.7). The association was not explained by maternal education. Early mortality was associated with diagnoses within several diagnostic categories prior to cancer diagnosis, including infectious (OR 1.5, 95% CI 1.1–2.0) and endocrine diseases (OR 1.6, 95% CI 1.02–2.5), blood (OR 3.3, 95% CI 2.1–5.1) and digestive disorders (OR 1.9, 95% CI 1.4–2.6), and symptoms with no specific diagnosis (OR 1.4, 95% CI 1.1–8).

Conclusion

Children with increased time in hospital before cancer diagnosis had a higher risk for early mortality, which indicates underlying health vulnerabilities or pre-existing fragility in this population.