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Background <p>One-third of all lung cancer cases globally are reported in China. This study evaluated the symptom management efficacy of an electronic patient-reported outcomes (ePRO)-based intervention for postoperative symptoms like pain and psychological distress after lung cancer surgery.</p> Methods <p>We included lung cancer surgery patients (April 2022–October 2023; age, 18–75 years) with ECOG scores of 0–2 and expected survival of &gt;6 months and randomized them into control and intervention groups. The latter completed MDASI-LC and QLQ-C30 questionnaires, wherein high symptom scores prompted treatment recommendations; the former received routine care. Changes in symptom scores, daily function, and quality of life were evaluated over 12 weeks and 1 year through surveys and interviews for ePRO-based symptom management efficacy assessments.</p> Results <p>Herein, 355 participants comprised intervention (<i>n</i> = 182) and control groups (<i>n</i> = 173). At 12 weeks, the former had significantly lower symptoms threshold [0 (0–1) <i>vs</i>. 1 (0–3)], lower symptom scores [adjusted mean difference, −0.527 (95% CI: −0.788 to −0.266)], and higher QOL scores (emotional function: 2.908; 95% CI: 0.600–5.216, <i>P</i> = 0.014; global health: 6.775; 95% CI: 3.967–9.583).</p> Conclusions <p>ePRO-based collaborative management effectively lessened postoperative burden and improved QOL beyond 6 months.</p>

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Physiological and psychological symptom management based on electronic patient-reported outcomes: the TD-WELLBEING randomized clinical trial

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月7日

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  • Pengyu Jing,
  • Ying Liang,
  • Zhijun Tan,
  • Xiaolong Yan,
  • Jie Lei,
  • Yunfeng Ni,
  • Ximing Zhu,
  • Chun Qiu,
  • Jian Wang,
  • Peng Ge,
  • Yong Zhang,
  • Lv Wang,
  • Nan Zhao,
  • Yong Zhang,
  • Juan Wang,
  • Yan Wang,
  • Chunlong Zheng,
  • Qiongjie Shao,
  • Haiyue Zhang,
  • Zhe Yang,
  • Haichao Li,
  • Jiangjiang Fan,
  • Siming Liu,
  • Kyriacos Kyriacou,
  • Lei Shang,
  • Zhongping Gu

摘要

Background

One-third of all lung cancer cases globally are reported in China. This study evaluated the symptom management efficacy of an electronic patient-reported outcomes (ePRO)-based intervention for postoperative symptoms like pain and psychological distress after lung cancer surgery.

Methods

We included lung cancer surgery patients (April 2022–October 2023; age, 18–75 years) with ECOG scores of 0–2 and expected survival of >6 months and randomized them into control and intervention groups. The latter completed MDASI-LC and QLQ-C30 questionnaires, wherein high symptom scores prompted treatment recommendations; the former received routine care. Changes in symptom scores, daily function, and quality of life were evaluated over 12 weeks and 1 year through surveys and interviews for ePRO-based symptom management efficacy assessments.

Results

Herein, 355 participants comprised intervention (n = 182) and control groups (n = 173). At 12 weeks, the former had significantly lower symptoms threshold [0 (0–1) vs. 1 (0–3)], lower symptom scores [adjusted mean difference, −0.527 (95% CI: −0.788 to −0.266)], and higher QOL scores (emotional function: 2.908; 95% CI: 0.600–5.216, P = 0.014; global health: 6.775; 95% CI: 3.967–9.583).

Conclusions

ePRO-based collaborative management effectively lessened postoperative burden and improved QOL beyond 6 months.