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Background <p>Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) is a chronic inflammatory disease that affects the oral mucosa. Different clinical types of oral lichen planus can be diagnosed based on clinical presentation and histopathological features.</p> Aim <p>The present study aimed to assess the potential of salivary and serum leptin in the diagnosis of OLP.</p> Materials &amp; Methods <p>The study was conducted on 78 cases (i.e., 39 cases per group) with OLP. The subjects were systematically free. Salivary and serum leptin concentrations from patients exhibiting a classic OLP and from healthy controls were assessed.</p> Results <p>Salivary and serum leptin levels are higher in the OLP group. The participants in the study are older than those in the control group; therefore, the age difference between the two groups does not affect the study’s results.</p> Conclusion <p>Salivary and serum leptin levels in OLP patients were higher than in healthy control subjects, suggesting a possible role in the process of OLP pathogenesis.</p>

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Salivary and serum leptin levels in oral lichen planus patients. A case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月5日

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  • Bahaa Mahmoud Fawzy El Nomrosy,
  • Weam Ahmed Maher Rashawn,
  • Olfat Gamil Shaker

摘要

Background

Lichen planus (LP) is a chronic inflammatory disease. Oral lichen planus (OLP) is a chronic inflammatory disease that affects the oral mucosa. Different clinical types of oral lichen planus can be diagnosed based on clinical presentation and histopathological features.

Aim

The present study aimed to assess the potential of salivary and serum leptin in the diagnosis of OLP.

Materials & Methods

The study was conducted on 78 cases (i.e., 39 cases per group) with OLP. The subjects were systematically free. Salivary and serum leptin concentrations from patients exhibiting a classic OLP and from healthy controls were assessed.

Results

Salivary and serum leptin levels are higher in the OLP group. The participants in the study are older than those in the control group; therefore, the age difference between the two groups does not affect the study’s results.

Conclusion

Salivary and serum leptin levels in OLP patients were higher than in healthy control subjects, suggesting a possible role in the process of OLP pathogenesis.