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<p>Depression is associated with a higher risk for developing Alzheimer’s Disease (AD) [1], but the mechanisms that underlie the complex relationship between depression and AD remain largely elusive. The hippocampus is a region of the brain that is commonly affected by both AD and depression and serves as a focal point for our study. We aim to understand the relationship of 1) depression and antidepressant medications to hippocampal subfield volume during normal aging, and 2) whether AD risk, as measured by amyloid and tau pathology and <i>APOE</i>4 status, impacts these relationships. We studied 2009 ethno-racially diverse cognitively unimpaired older adults aged 50 to 90 years who either had depression (<i>n</i> = 630) or were not depressed (<i>n</i> = 1379). Participants with depression were further stratified by antidepressant medication usage. High-resolution MRI scans were used to calculate hippocampal subfield volumes that included the CA1, the subiculum, and a composite region that included the CA2, CA3, and the dentate gyrus (CA23DG). Having depression was associated with a smaller CA23DG, independent of amyloid and tau pathology in the brain. Within the subgroup of participants with depression, those who used antidepressant medications had smaller CA1 and CA23DG volumes than those who did not use these medications.</p>

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Depression and hippocampal subfield volume in older adults

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月14日

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  • Danielle Luu,
  • Alicia M. Twisselmann,
  • Victoria R. Tennant,
  • Brandon J. Hall,
  • Arjun Mahajan,
  • Audrey Kim,
  • Jamie Terner,
  • Marylan L. Davison,
  • Koral Wheeler,
  • Christopher R. K. Ching,
  • James Hall,
  • Matthew T. Borzage,
  • Leigh Johnson,
  • Arthur W. Toga,
  • Sid E. O’Bryant,
  • Kristine Yaffe,
  • Meredith N. Braskie,
  • Arthur Toga,
  • Robert Rissman,
  • Meredith Braskie,
  • Kevin King,
  • James R. Hall,
  • Melissa Petersen,
  • Raymond Palmer,
  • Robert Barber,
  • Yonggang Shi,
  • Fan Zhang,
  • Rajesh Nandy,
  • Roderick McColl,
  • David Mason,
  • Bradley Christian,
  • Nicole Phillips,
  • Stephanie Large,
  • Joe Lee,
  • Badri Vardarajan,
  • Monica Rivera Mindt,
  • Amrita Cheema,
  • Lisa Barnes,
  • Mark Mapstone,
  • Annie Cohen,
  • Amy Kind,
  • Ozioma Okonkwo,
  • Raul Vintmilla,
  • Zhengyang Zhou,
  • Michael Donohue,
  • Rema Raman,
  • Matthew Borzage,
  • Michelle Mielke,
  • Beau Ances,
  • Ganesh Babulal,
  • Jorge Llibre-Guerra,
  • Carl Hill,
  • Rocky Vig

摘要

Depression is associated with a higher risk for developing Alzheimer’s Disease (AD) [1], but the mechanisms that underlie the complex relationship between depression and AD remain largely elusive. The hippocampus is a region of the brain that is commonly affected by both AD and depression and serves as a focal point for our study. We aim to understand the relationship of 1) depression and antidepressant medications to hippocampal subfield volume during normal aging, and 2) whether AD risk, as measured by amyloid and tau pathology and APOE4 status, impacts these relationships. We studied 2009 ethno-racially diverse cognitively unimpaired older adults aged 50 to 90 years who either had depression (n = 630) or were not depressed (n = 1379). Participants with depression were further stratified by antidepressant medication usage. High-resolution MRI scans were used to calculate hippocampal subfield volumes that included the CA1, the subiculum, and a composite region that included the CA2, CA3, and the dentate gyrus (CA23DG). Having depression was associated with a smaller CA23DG, independent of amyloid and tau pathology in the brain. Within the subgroup of participants with depression, those who used antidepressant medications had smaller CA1 and CA23DG volumes than those who did not use these medications.