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<p>The Behavioral Inhibition and Activation Systems (BIS/BAS) are central to emotional regulation, yet their genetic and neural mechanisms remain unclear. In this study, we examined how polygenic risk for BIS/BAS relates to striatal structural connectivity and emotional vulnerability during adolescence—a critical period for affective problems onset. Using data from 1,929 adolescents (average age 9.95 years, 50.39% female) in the ABCD Study, we found that BIS and BAS polygenic risks exerted dissociable influences on striatal structural gradient (SSG), delineating distinct neurobiological pathways to anxiety and depression. Elevated BIS risk was linked to greater anxiety symptoms, whereas increased BAS risk related more strongly to depressive and withdrawn features. Altogether, our findings elucidate a neuroanatomical pleiotropy mechanism, whereby shared striatal connectivity architectures differentially channel genetic susceptibilities into distinct symptom dimensions, thereby advancing our understanding of the neural pathways underlying emotional vulnerability across diverse psychiatric phenotypes.</p><p></p>

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Genetic and striatal structural connection linking behavioral inhibition/activation system to adolescent anxiety and depression

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月31日

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  • Jing Lou,
  • Xiaohan Tian,
  • Yuqing Sun,
  • Junxing Xian,
  • Wenkun Lei,
  • Meng Wang,
  • Bing Liu

摘要

The Behavioral Inhibition and Activation Systems (BIS/BAS) are central to emotional regulation, yet their genetic and neural mechanisms remain unclear. In this study, we examined how polygenic risk for BIS/BAS relates to striatal structural connectivity and emotional vulnerability during adolescence—a critical period for affective problems onset. Using data from 1,929 adolescents (average age 9.95 years, 50.39% female) in the ABCD Study, we found that BIS and BAS polygenic risks exerted dissociable influences on striatal structural gradient (SSG), delineating distinct neurobiological pathways to anxiety and depression. Elevated BIS risk was linked to greater anxiety symptoms, whereas increased BAS risk related more strongly to depressive and withdrawn features. Altogether, our findings elucidate a neuroanatomical pleiotropy mechanism, whereby shared striatal connectivity architectures differentially channel genetic susceptibilities into distinct symptom dimensions, thereby advancing our understanding of the neural pathways underlying emotional vulnerability across diverse psychiatric phenotypes.