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<p>Liver transplantation is the only curative option for patients with advanced stages of liver disease, with tacrolimus used as the immunosuppressive drug of choice. Genetic variability can interfere with drug response, potentially leading to overexposure or underexposure. This study aims to investigate the association of CYP3A4 (rs2740574, rs2242480, rs35599367), CYP3A5 (rs776746, rs10264272), POR (rs1057868) and ABCB1 (rs1128503, rs2229109, rs9282564) gene polymorphisms with infection, acute rejection, and renal failure. The logistic regression model found an influence of CYP3A5 (rs776746) and POR28 (rs1057868) on the development of acute rejection after liver transplantation (<i>p</i> = 0.028). It also found an association between carriers of the variant allele of the POR*28 gene and infection.</p>

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CYP3A5 and POR gene polymorphisms as predictors of infection and graft rejection in post-liver transplant patients treated with tacrolimus - a cohort study

  • 期刊论文

  • 发表日期：

    2025年2月25日

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  • Graziella D’ Agostino Ribeiro Naldi,
  • Ariane Boccoli Minari,
  • Thales D. M. Pereira,
  • Victor Fossaluza,
  • Nicholas Wagner Eugenio,
  • Marcelo Alves Ferreira,
  • Guilherme H. Gregório,
  • Lucas Nacif,
  • Luiz Augusto Carneiro D Albuquerque,
  • Ricardo di Lazzaro Filho,
  • Eduardo Luiz Rachid Cançado,
  • Suzane Kioko Ono

摘要

Liver transplantation is the only curative option for patients with advanced stages of liver disease, with tacrolimus used as the immunosuppressive drug of choice. Genetic variability can interfere with drug response, potentially leading to overexposure or underexposure. This study aims to investigate the association of CYP3A4 (rs2740574, rs2242480, rs35599367), CYP3A5 (rs776746, rs10264272), POR (rs1057868) and ABCB1 (rs1128503, rs2229109, rs9282564) gene polymorphisms with infection, acute rejection, and renal failure. The logistic regression model found an influence of CYP3A5 (rs776746) and POR28 (rs1057868) on the development of acute rejection after liver transplantation (p = 0.028). It also found an association between carriers of the variant allele of the POR*28 gene and infection.