Scholarlink

Study Design <p>Retrospective, randomised controlled, monocentric, longitudinal cohort study.</p> Objectives <p>To evaluate data from outpatient clinical practice to determine whether the chosen ventilation mode (PCV or VCV) affects the rate of pneumonia, post-discharge survival&#xa0;and mortality, with the aim of ensuring appropriate long-term ventilation outside the hospital for tetraplegic patients on invasive long-term ventilation.</p> Setting <p>Data collection and patient examinations were conducted&#xa0;in a german clinical setting (BG Trauma Hospital&#xa0;Hamburg), while long-term ventilation and outpatient intensive care were provided&#xa0;exclusively outside the hospital setting&#xa0;in the patients’ home environment in Germany.</p> Methods <p>Over a period of 35 years (01.01.1985 - 31.12.2019), two patient cohorts (Level of lesion C2-C4) permanently invasive ventilated either pressure-controlled (PCV <i>n</i> = 21) or volume-controlled (VCV n = 21) due to complete diaphragm paralysis were examined at regular intervals of 1-2 years. A group&#xa0;of patients with spinal cord injury (n = 83),&#xa0;level of lesion&#xa0;C4-C6 AIS A, that had not received mechanical ventilation at any point prior to the study proper word was randomised&#xa0;and used as a control group.</p> Results <p>Neither PCV nor VCV have significant influence on the pneumonia rate, the out-of-hospital survival and the mortality. As expected, there were significant differences between the ventilated group and the non-ventilated control group. Within the ventilated group, both pneumonia rates and mortality were higher and survival times significantly shorter.</p> Conclusion <p>It has been confirmed for the out-of-hospital setting that the selected ventilation mode has no influence on the pneumonia rate, out-of-hospital survival time and mortality. In addition, with regard to the risks of invasive long-term ventilation, the key &#xa0;finding of this study is that a pressure- or volume-controlled ventilation mode can be selected without weighing additional medical risks and that this mode&#xa0;can also be changed during long-term ventilation.</p> Sponsorship <p>This study was not funded by a sponsor.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

35 years of long-term invasive mechanical ventilation in high tetraplegic patients due to chronic respiratory failure - comparative results of pressure- (PCV) and volume-controlled ventilation (VCV) in the out-of-hospital setting

  • 期刊论文

  • 发表日期：

    2026年5月14日

查看全文
  • Sven Hirschfeld,
  • Birgitt Kowald,
  • Roland Thietje,
  • Merle Rudolph

摘要

Study Design

Retrospective, randomised controlled, monocentric, longitudinal cohort study.

Objectives

To evaluate data from outpatient clinical practice to determine whether the chosen ventilation mode (PCV or VCV) affects the rate of pneumonia, post-discharge survival and mortality, with the aim of ensuring appropriate long-term ventilation outside the hospital for tetraplegic patients on invasive long-term ventilation.

Setting

Data collection and patient examinations were conducted in a german clinical setting (BG Trauma Hospital Hamburg), while long-term ventilation and outpatient intensive care were provided exclusively outside the hospital setting in the patients’ home environment in Germany.

Methods

Over a period of 35 years (01.01.1985 - 31.12.2019), two patient cohorts (Level of lesion C2-C4) permanently invasive ventilated either pressure-controlled (PCV n = 21) or volume-controlled (VCV n = 21) due to complete diaphragm paralysis were examined at regular intervals of 1-2 years. A group of patients with spinal cord injury (n = 83), level of lesion C4-C6 AIS A, that had not received mechanical ventilation at any point prior to the study proper word was randomised and used as a control group.

Results

Neither PCV nor VCV have significant influence on the pneumonia rate, the out-of-hospital survival and the mortality. As expected, there were significant differences between the ventilated group and the non-ventilated control group. Within the ventilated group, both pneumonia rates and mortality were higher and survival times significantly shorter.

Conclusion

It has been confirmed for the out-of-hospital setting that the selected ventilation mode has no influence on the pneumonia rate, out-of-hospital survival time and mortality. In addition, with regard to the risks of invasive long-term ventilation, the key  finding of this study is that a pressure- or volume-controlled ventilation mode can be selected without weighing additional medical risks and that this mode can also be changed during long-term ventilation.

Sponsorship

This study was not funded by a sponsor.