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Background <p>For de-novo oligometastatic prostate cancer (omHSPC) treated with standard of care androgen suppression and prostate radiotherapy, the patterns of progression vis-a-vis index metastatic sites are not well understood.</p> Methods <p>This single-centre study included patients with de-novo omHSPC (CHAARTED criteria) staged with a PSMA-PET/CT scan at diagnosis, treated with systemic therapy and prostate radiotherapy, and re-staged with PSMA-PET/CT at biochemical progression. Disease status at index oligometastases was noted at progression.</p> Results <p>From 2015 to 2024, 79 patients with omHSPC were found eligible (M1a = 22, M1b = 57). Over a median follow-up of 39 months (IQR 28–69), 15 patients (19%) had disease progression. Restaging PSMA-PET/CT revealed progression of the index oligometastases for 11/15 patients (73%), with additional metastases in 7 of these.</p> Conclusion <p>The high proportion of progression at the index oligometastases supports the potential benefit of metastasis-directed therapy for local ablation.</p>

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Progression of index metastases in oligometastatic hormone-sensitive prostate cancer: implications for metastases directed therapy?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月11日

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  • Parth Verma,
  • Priyamvada Maitre,
  • Gowtham Surya Krishnasamy,
  • Nishika Murarka,
  • Sayak Choudhury,
  • Suchismita Ghosh,
  • Archi Agrawal,
  • Vedang Murthy

摘要

Background

For de-novo oligometastatic prostate cancer (omHSPC) treated with standard of care androgen suppression and prostate radiotherapy, the patterns of progression vis-a-vis index metastatic sites are not well understood.

Methods

This single-centre study included patients with de-novo omHSPC (CHAARTED criteria) staged with a PSMA-PET/CT scan at diagnosis, treated with systemic therapy and prostate radiotherapy, and re-staged with PSMA-PET/CT at biochemical progression. Disease status at index oligometastases was noted at progression.

Results

From 2015 to 2024, 79 patients with omHSPC were found eligible (M1a = 22, M1b = 57). Over a median follow-up of 39 months (IQR 28–69), 15 patients (19%) had disease progression. Restaging PSMA-PET/CT revealed progression of the index oligometastases for 11/15 patients (73%), with additional metastases in 7 of these.

Conclusion

The high proportion of progression at the index oligometastases supports the potential benefit of metastasis-directed therapy for local ablation.