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Background <p>To report active surveillance (AS) outcomes in patients with Grade Group (GG) 2 prostate cancer (PCa) according to the baseline amount of pattern 4 on image-guided biopsy.</p> Methods <p>Our database includes GG2 PCa patients managed with AS in ten European centers.</p> Results <p>In total, 104 patients were included (median pattern 4: 10%, ranges 5–40). The percentage of pattern 4 was not statistically correlated with upgrading (Spearman, r = 0.073, p = 0.5) or downgrading on confirmatory biopsy (r = −0.049, p = 0.6). The median follow-up was 33 months. In multivariable Cox regression analysis, percentage of pattern 4 was not associated with GG3 upgrading (p = 0.6) or definitive treatment (p = 0.4).</p> Conclusions <p>Patients with GG2 PCa should not be excluded from AS solely because of grade 4 &gt; 10% when other parameters are otherwise favorable.</p>

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Gleason pattern 4 and active surveillance in patients with grade group 2 prostate cancer

  • 期刊论文

  • 发表日期：

    2025年4月29日

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  • Alessandro Uleri,
  • Michael Baboudjian,
  • Riccardo Leni,
  • Marco Oderda,
  • Arthur Peyrottes,
  • Claudia Kesch,
  • Mulham Al-Nader,
  • Charles Dariane,
  • Helene Baud,
  • Jonathan Olivier,
  • Anna Redondo Rios,
  • Francesco Sanguedolce,
  • Vincent Benard,
  • Olivier Windisch,
  • Massimo Valerio,
  • Giorgio Gandaglia,
  • Guillaume Ploussard

摘要

Background

To report active surveillance (AS) outcomes in patients with Grade Group (GG) 2 prostate cancer (PCa) according to the baseline amount of pattern 4 on image-guided biopsy.

Methods

Our database includes GG2 PCa patients managed with AS in ten European centers.

Results

In total, 104 patients were included (median pattern 4: 10%, ranges 5–40). The percentage of pattern 4 was not statistically correlated with upgrading (Spearman, r = 0.073, p = 0.5) or downgrading on confirmatory biopsy (r = −0.049, p = 0.6). The median follow-up was 33 months. In multivariable Cox regression analysis, percentage of pattern 4 was not associated with GG3 upgrading (p = 0.6) or definitive treatment (p = 0.4).

Conclusions

Patients with GG2 PCa should not be excluded from AS solely because of grade 4 > 10% when other parameters are otherwise favorable.