Scholarlink

Background <p>To investigated trends in postnatal and after-discharge growth outcomes during changes in nutritional practices over time in extremely preterm infants with necrotizing enterocolitis (NEC).</p> Methods <p>This multicenter cohort study enrolled 3046 infants born at &lt;28 weeks’ gestation between 2006 and 2019. Growth trajectories by z-scores of body weight (zBW) and head circumference (zHC) from neonatal-intensive-care-unit discharge to corrected age 24 months were analyzed across NEC severity (no/stage-I NEC, stage-II, stage-III) and epochs (1: 2006–2009; 2: 2010–2014; 3: 2015–2019) after propensity-score-matching (PSM).</p> Results <p>The PSM cohort included the stage-II (<i>n</i> = 221), stage-III (<i>n</i> = 103), and no/stage-I NEC (<i>n</i> = 972) groups. The stage-II/III NEC groups had significantly lower zBW and zHC compared to the no/stage-I NEC group at discharge during Epochs 2 and 3. After discharge, the stage-II NEC group achieved comparable zBW and zHC to the no/stage-I NEC group by 6–24 months in all epochs. In contrast, the stage-III NEC group displayed zBW improvement between 12 and 24 months in Epochs 2 and 3, but continued to have lower zHC from discharge to 24 months throughout all epochs.</p> Conclusions <p>As the general nutritional practices advanced, preterm infants with stage-III NEC consistently exhibited head growth deficits through 24 months of age.</p> Impact <p>For infants born extremely preterm in the three epochs of evolution in nutritional practices:<UnorderedList Mark="Bullet"> <ItemContent> <p>By discharge, infants with stage-II or stage-III NEC had significantly lower mean z-scores of body weight and head circumference compared to those with no/stage-I NEC.</p> </ItemContent> <ItemContent> <p>By age 6 to 24 months, infants with stage-II NEC caught up in weight and head growth with the no/stage-I NEC group.</p> </ItemContent> <ItemContent> <p>Infants with stage-III NEC caught up in weight growth with the no/stage-I NEC group between age 12 and 24 months, but persistently lagged behind in head growth up to 24 months throughout all epochs.</p> </ItemContent> </UnorderedList></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Growth outcome trends after necrotizing enterocolitis in preterm infants across changes in nutritional practices

  • 期刊论文

  • 发表日期：

    2025年12月17日

查看全文
  • Lan-Wan Wang,
  • Chi-Hsiang Chu,
  • Yung-Chieh Lin,
  • Chao-Ching Huang,
  • Jui-Hsing Chang,
  • Chyong-Hsin Hsu,
  • Po-Nien Tsao,
  • Shu-Chi Mu,
  • Mei-Jy Jeng,
  • Re-Yin Lien,
  • Hung-Chih Lin,
  • Ming-Jyh Lin,
  • Inn-Chi Lee,
  • Chien-Chou Hsiao,
  • Hsiu-Lin Chen,
  • Chih-Cheng Chen,
  • Hsiao-Ping Wang

摘要

Background

To investigated trends in postnatal and after-discharge growth outcomes during changes in nutritional practices over time in extremely preterm infants with necrotizing enterocolitis (NEC).

Methods

This multicenter cohort study enrolled 3046 infants born at <28 weeks’ gestation between 2006 and 2019. Growth trajectories by z-scores of body weight (zBW) and head circumference (zHC) from neonatal-intensive-care-unit discharge to corrected age 24 months were analyzed across NEC severity (no/stage-I NEC, stage-II, stage-III) and epochs (1: 2006–2009; 2: 2010–2014; 3: 2015–2019) after propensity-score-matching (PSM).

Results

The PSM cohort included the stage-II (n = 221), stage-III (n = 103), and no/stage-I NEC (n = 972) groups. The stage-II/III NEC groups had significantly lower zBW and zHC compared to the no/stage-I NEC group at discharge during Epochs 2 and 3. After discharge, the stage-II NEC group achieved comparable zBW and zHC to the no/stage-I NEC group by 6–24 months in all epochs. In contrast, the stage-III NEC group displayed zBW improvement between 12 and 24 months in Epochs 2 and 3, but continued to have lower zHC from discharge to 24 months throughout all epochs.

Conclusions

As the general nutritional practices advanced, preterm infants with stage-III NEC consistently exhibited head growth deficits through 24 months of age.

Impact

For infants born extremely preterm in the three epochs of evolution in nutritional practices:

By discharge, infants with stage-II or stage-III NEC had significantly lower mean z-scores of body weight and head circumference compared to those with no/stage-I NEC.

By age 6 to 24 months, infants with stage-II NEC caught up in weight and head growth with the no/stage-I NEC group.

Infants with stage-III NEC caught up in weight growth with the no/stage-I NEC group between age 12 and 24 months, but persistently lagged behind in head growth up to 24 months throughout all epochs.