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Background <p>Maternal and newborn vitamin D levels are closely linked, but the role of genetic factors is not fully understood. This study investigates how maternal vitamin D levels and variations in vitamin D metabolism genes influence cord blood vitamin D concentrations.</p> Methods <p>A total of 456 mother–newborn pairs were included. Maternal blood was collected during the second trimester (24–28 weeks), and cord blood at birth. Genetic polymorphisms in vitamin D receptor (<i>VDR</i>), vitamin D binding protein (<i>VDBP</i>), and cytochrome P450 27B1 (<i>CYP27B1</i>) genes were genotyped. Linear regression and other statistical methods assessed associations with cord blood vitamin D levels.</p> Results <p>Maternal and newborn vitamin D levels showed a linear correlation (R² = 0.3854, <i>p</i> &lt; 0.001). Maternal <i>CYP27B1</i> rs10877012 and the G allele count in mother–newborn pairs were significantly associated with cord blood levels (<i>p</i> = 0.0009). The newborn-to-maternal vitamin D ratio, reflecting transfer efficiency, was influenced by <i>VDBP</i> variants (maternal rs4588, <i>p</i> = 0.0203; newborn rs7041, <i>p</i> = 0.0171).</p> Conclusion <p>Maternal vitamin D status is the key driver of cord blood vitamin D levels, with genetic variants in <i>CYP27B1</i> and VDBP playing additional roles in determining both the levels and the efficiency of vitamin D transfer from mother to newborn.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Demonstrates a strong linear correlation between maternal and newborn vitamin D levels.</p> </ItemContent> <ItemContent> <p>Identifies a significant association between maternal <i>CYP27B1</i> polymorphism (rs10877012) and cord blood vitamin D concentration.</p> </ItemContent> <ItemContent> <p>Shows that <i>VDBP</i> genetic variants influence the efficiency of vitamin D transfer from mother to fetus.</p> </ItemContent> <ItemContent> <p>Supports the development of personalized vitamin D supplementation strategies for pregnant women to optimize neonatal outcomes.</p> </ItemContent> </UnorderedList></p>

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Maternal vitamin D and genetic variants determine cord blood vitamin D levels in newborn

  • 期刊论文

  • 发表日期：

    2025年10月15日

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  • Ming-Luen Tsai,
  • Miao-His Hsieh,
  • Chih-Yi Yang,
  • Pei-Chi Chen,
  • Wen-Shuo Kao,
  • Xiao-Ling Liu,
  • Yi-Hsuan Lee,
  • Yi-Shan Tseng,
  • Jiu-Yao Wang,
  • Lawrence Shih-Hsin Wu

摘要

Background

Maternal and newborn vitamin D levels are closely linked, but the role of genetic factors is not fully understood. This study investigates how maternal vitamin D levels and variations in vitamin D metabolism genes influence cord blood vitamin D concentrations.

Methods

A total of 456 mother–newborn pairs were included. Maternal blood was collected during the second trimester (24–28 weeks), and cord blood at birth. Genetic polymorphisms in vitamin D receptor (VDR), vitamin D binding protein (VDBP), and cytochrome P450 27B1 (CYP27B1) genes were genotyped. Linear regression and other statistical methods assessed associations with cord blood vitamin D levels.

Results

Maternal and newborn vitamin D levels showed a linear correlation (R² = 0.3854, p < 0.001). Maternal CYP27B1 rs10877012 and the G allele count in mother–newborn pairs were significantly associated with cord blood levels (p = 0.0009). The newborn-to-maternal vitamin D ratio, reflecting transfer efficiency, was influenced by VDBP variants (maternal rs4588, p = 0.0203; newborn rs7041, p = 0.0171).

Conclusion

Maternal vitamin D status is the key driver of cord blood vitamin D levels, with genetic variants in CYP27B1 and VDBP playing additional roles in determining both the levels and the efficiency of vitamin D transfer from mother to newborn.

Impact

Demonstrates a strong linear correlation between maternal and newborn vitamin D levels.

Identifies a significant association between maternal CYP27B1 polymorphism (rs10877012) and cord blood vitamin D concentration.

Shows that VDBP genetic variants influence the efficiency of vitamin D transfer from mother to fetus.

Supports the development of personalized vitamin D supplementation strategies for pregnant women to optimize neonatal outcomes.