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Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Rhesus rotavirus (RRV) infection primes biliary epithelial cells to respond hyperactively to low-dose lipopolysaccharide (LPS), triggering upregulation of matrix metalloproteinase-7 (MMP7) via TLR4/NF-κB signaling.</p> </ItemContent> <ItemContent> <p>Loss of endotoxin tolerance in biliary atresia (BA), associated with reduced expression of IRAK-M, leads to uncontrolled inflammation and tissue damage.</p> </ItemContent> <ItemContent> <p>MMP7 acts as a dual-function molecule, contributing to both extracellular matrix remodeling and amplification of inflammatory signaling in BA.</p> </ItemContent> <ItemContent> <p>Targeting the TLR4/NF-κB/MMP7 signaling axis represents a promising therapeutic strategy with potential applications in disease modification and early diagnosis of BA.</p> </ItemContent> </UnorderedList></p>

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A two-hit model in biliary atresia: cooperative viral-bacterial activation of MMP7 via TLR4/NF-κB signaling

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • Khaled Saad,
  • Mostafa M. Embaby,
  • Thamer A. M. Alruwaili,
  • Amira Elhoufey,
  • Mohamad-Hani Temsah,
  • Wesam M. Hussein,
  • Mohamed Abdelsaboor,
  • Khalid Hashim Mahmoud

摘要

Impact

Rhesus rotavirus (RRV) infection primes biliary epithelial cells to respond hyperactively to low-dose lipopolysaccharide (LPS), triggering upregulation of matrix metalloproteinase-7 (MMP7) via TLR4/NF-κB signaling.

Loss of endotoxin tolerance in biliary atresia (BA), associated with reduced expression of IRAK-M, leads to uncontrolled inflammation and tissue damage.

MMP7 acts as a dual-function molecule, contributing to both extracellular matrix remodeling and amplification of inflammatory signaling in BA.

Targeting the TLR4/NF-κB/MMP7 signaling axis represents a promising therapeutic strategy with potential applications in disease modification and early diagnosis of BA.