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Background <p>Children exposed antenatally to Zika virus (ZIKV) during the 2015-2016 epidemic are now in school; little is known about their neurodevelopment at this age. The objective was to evaluate neurodevelopment of ZIKV-exposed Colombian children compared to non-exposed controls at ages 5–6.</p> Methods <p>In total, 48 normocephalic children with antenatal ZIKV exposure (Cases) were recruited for a longitudinal cohort study in Atlántico, Colombia. Two age-matched control groups of 118 non-ZIKV-exposed children were recruited from same communities as Cases: 63 born before ZIKV epidemic but experienced COVID-19-related school entry delays, and 55 born post-ZIKV epidemic but started school on time. Multi-domain neurodevelopment was assessed at 5–6 years using standardized measures. Standard regression and proportional odds models were used to compare outcomes. <i>P</i> values were adjusted using the Benjamini-Hochberg false discovery rate (FDR) (<i>p</i> &lt; 0.05).</p> Results <p>There were no differences in age at assessment between groups. Case Full-Scale IQ scores were lower than both control groups (<i>p</i> = 0.002), driven by visual reasoning (<i>p</i> &lt; 0.001). Controls with school entry delay had more executive control problems and lower adaptive functioning skills than Cases and Controls without school entry delay.</p> Conclusions <p>ZIKV-exposed children have lower cognitive performance compared to controls. Early childhood experiences can affect pediatric outcomes research.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>Normocephalic ZIKV-exposed children have lower full-scale IQ than their unexposed peers from the same communities.</p> </ItemContent> <ItemContent> <p>Normocephalic children with antenatal ZIKV exposure have differences in neurodevelopment that can impact them long-term.</p> </ItemContent> <ItemContent> <p>There is a need for continued follow-up of children with antenatal ZIKV exposure to determine long-term effects on higher-order areas of cognitive function.</p> </ItemContent> </UnorderedList></p>

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School-age child neurodevelopment following antenatal Zika virus exposure

  • 期刊论文

  • 发表日期：

    2025年3月19日

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  • Sarah B. Mulkey,
  • Regan Andringa-Seed,
  • Elizabeth Corn,
  • Meagan E. Williams,
  • Margarita Arroyave-Wessel,
  • Robert H. Podolsky,
  • Colleen Peyton,
  • Michael E. Msall,
  • Carlos Cure,
  • Madison M. Berl

摘要

Background

Children exposed antenatally to Zika virus (ZIKV) during the 2015-2016 epidemic are now in school; little is known about their neurodevelopment at this age. The objective was to evaluate neurodevelopment of ZIKV-exposed Colombian children compared to non-exposed controls at ages 5–6.

Methods

In total, 48 normocephalic children with antenatal ZIKV exposure (Cases) were recruited for a longitudinal cohort study in Atlántico, Colombia. Two age-matched control groups of 118 non-ZIKV-exposed children were recruited from same communities as Cases: 63 born before ZIKV epidemic but experienced COVID-19-related school entry delays, and 55 born post-ZIKV epidemic but started school on time. Multi-domain neurodevelopment was assessed at 5–6 years using standardized measures. Standard regression and proportional odds models were used to compare outcomes. P values were adjusted using the Benjamini-Hochberg false discovery rate (FDR) (p < 0.05).

Results

There were no differences in age at assessment between groups. Case Full-Scale IQ scores were lower than both control groups (p = 0.002), driven by visual reasoning (p < 0.001). Controls with school entry delay had more executive control problems and lower adaptive functioning skills than Cases and Controls without school entry delay.

Conclusions

ZIKV-exposed children have lower cognitive performance compared to controls. Early childhood experiences can affect pediatric outcomes research.

Impact

Normocephalic ZIKV-exposed children have lower full-scale IQ than their unexposed peers from the same communities.

Normocephalic children with antenatal ZIKV exposure have differences in neurodevelopment that can impact them long-term.

There is a need for continued follow-up of children with antenatal ZIKV exposure to determine long-term effects on higher-order areas of cognitive function.