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<p>Brain insulin action was measured in adolescents with (cases) and without (controls) depression, by calculating the difference in resting-state functional connectivity (ΔrsFC) following an intranasal insulin challenge. A significant Group × Condition interaction effect was identified: controls exhibited greater ΔrsFC with intranasal insulin compared to cases in brain regions regulating cognitive/emotional processing.</p>

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Is abnormal brain insulin action implicated in the biology of depression? A pilot neuroimaging study in adolescents

  • 期刊论文

  • 发表日期：

    2026年7月11日

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  • Kateryna Maksyutynska,
  • Nicolette Stogios,
  • Vittal Korann,
  • Laurie Hamel,
  • Daphne Korczak,
  • Benjamin I. Goldstein,
  • Gary Remington,
  • Marcos Sanches,
  • Margaret K. Hahn,
  • Ariel Graff-Guerrero,
  • Sri Mahavir Agarwal

摘要

Brain insulin action was measured in adolescents with (cases) and without (controls) depression, by calculating the difference in resting-state functional connectivity (ΔrsFC) following an intranasal insulin challenge. A significant Group × Condition interaction effect was identified: controls exhibited greater ΔrsFC with intranasal insulin compared to cases in brain regions regulating cognitive/emotional processing.