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<p>Within the cortico-basal ganglia network, the volume and functional connectivity (FC) of the globus pallidus (GP) are altered in schizophrenia-spectrum disorders, with GP enlargement being relatively specific to schizophrenia compared to other disorders. However, little is known about alterations in its two major segments, externus (GPe) and internus (GPi), in schizophrenia-spectrum disorders. In this study, we compared GPe/GPi volume and FC between patients with schizophrenia and controls (<i>n</i> &gt; 100), and examined the associations of GPe/GPi volume and FC with subclinical psychotic experiences (SPEs) in early adolescents (<i>n</i> &gt; 200). We found GPe-dominant enlargement and GP subregion-specific FC patterns (e.g., increased left GPe FC with the lateral occipitoparietal area and decreased left GPi FC with the precuneus) in schizophrenia. Additionally, we observed a positive association between GPe volume and SPEs in adolescence, as well as GP subregion-specific FC patterns (e.g., larger left GPe FC with the lingual gyrus) in adolescents with SPEs compared to those without. Future translational studies are needed to elucidate the mechanisms underlying such GP subregion-specific neurophysiological roles.</p>

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The role of the globus pallidus subregions in the schizophrenia spectrum continuum

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Naohiro Okada,
  • Kentaro Morita,
  • Shimon Tonsho,
  • Masahiro Kiyota,
  • Eimu Shoji,
  • Daisuke Koshiyama,
  • Shinsuke Koike,
  • Syudo Yamasaki,
  • Atsushi Nishida,
  • Shuntaro Ando,
  • Noriaki Yahata,
  • Kouhei Kamiya,
  • Akira Kunimatsu,
  • Osamu Abe,
  • Sho Yagishita,
  • Kiyoto Kasai

摘要

Within the cortico-basal ganglia network, the volume and functional connectivity (FC) of the globus pallidus (GP) are altered in schizophrenia-spectrum disorders, with GP enlargement being relatively specific to schizophrenia compared to other disorders. However, little is known about alterations in its two major segments, externus (GPe) and internus (GPi), in schizophrenia-spectrum disorders. In this study, we compared GPe/GPi volume and FC between patients with schizophrenia and controls (n > 100), and examined the associations of GPe/GPi volume and FC with subclinical psychotic experiences (SPEs) in early adolescents (n > 200). We found GPe-dominant enlargement and GP subregion-specific FC patterns (e.g., increased left GPe FC with the lateral occipitoparietal area and decreased left GPi FC with the precuneus) in schizophrenia. Additionally, we observed a positive association between GPe volume and SPEs in adolescence, as well as GP subregion-specific FC patterns (e.g., larger left GPe FC with the lingual gyrus) in adolescents with SPEs compared to those without. Future translational studies are needed to elucidate the mechanisms underlying such GP subregion-specific neurophysiological roles.