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Background <p>Peripartum depression (PPD) is a form of major depressive disorder (MDD) that begins during the peripartum period and poses a significant mental health challenge affecting 10 to 29% of women.</p> Objective <p>This systematic review and multimodal activation likelihood estimation (ALE) meta-analysis explored the distinct structural, functional, and metabolic features of the PPD brain as compared to female non-peripartum MDD.</p> Methods <p>For this purpose, we conducted a comprehensive literature search in PubMed, Embase and PsycINFO databases to identify peer-reviewed original studies investigating the neural correlates associated with PPD or fMDD.</p> Results <p>Forty-five studies in PPD and 55 in fMDD were included in the qualitative synthesis. From these, 25 PPD and 32 fMDD studies were included in the meta-analysis. Both shared and distinct neural underpinnings of PPD and fMDD were observed. Specifically, we found alterations in the cognitive control, salience and default mode networks for both PPD and fMDD, although with reversed structural and functional activity patterns in the insula, amygdala, precentral gyrus and precuneus.</p> Conclusions <p>These findings support the consistent pattern of dysregulation associated with emotional regulation, cognition and maternal caregiving in women with PPD, as well as possible differential sensitivity to hormonal influences, highlighting the need for targeted interventions.</p>

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Neural correlates of peripartum depression: a systematic review, meta-analysis and comparison to major depressive disorder

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月8日

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  • Mónica Sobral,
  • Raquel Guiomar,
  • Manya Rezaeian,
  • Maria Vasileiadi,
  • Sara Cruz,
  • Francisca Pacheco,
  • Vera Mateus,
  • Roser Palau-Costafreda,
  • Johanna Pozo-Neira,
  • Ana Weidenauer,
  • Helena Moreira,
  • Martin Tik,
  • Ana Ganho-Ávila,
  • Anna-Lisa Schuler

摘要

Background

Peripartum depression (PPD) is a form of major depressive disorder (MDD) that begins during the peripartum period and poses a significant mental health challenge affecting 10 to 29% of women.

Objective

This systematic review and multimodal activation likelihood estimation (ALE) meta-analysis explored the distinct structural, functional, and metabolic features of the PPD brain as compared to female non-peripartum MDD.

Methods

For this purpose, we conducted a comprehensive literature search in PubMed, Embase and PsycINFO databases to identify peer-reviewed original studies investigating the neural correlates associated with PPD or fMDD.

Results

Forty-five studies in PPD and 55 in fMDD were included in the qualitative synthesis. From these, 25 PPD and 32 fMDD studies were included in the meta-analysis. Both shared and distinct neural underpinnings of PPD and fMDD were observed. Specifically, we found alterations in the cognitive control, salience and default mode networks for both PPD and fMDD, although with reversed structural and functional activity patterns in the insula, amygdala, precentral gyrus and precuneus.

Conclusions

These findings support the consistent pattern of dysregulation associated with emotional regulation, cognition and maternal caregiving in women with PPD, as well as possible differential sensitivity to hormonal influences, highlighting the need for targeted interventions.