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<p>Intelligent wound management necessitates flexible and personalized wound dressings capable of real-time physiological monitoring and targeted therapeutic interventions. A significant challenge lies in integrating diverse sensing and stimulation components into an all-in-one dressing while maintaining material compatibility and structural interoperability. Here, we present a sophisticated and scalable flexible diagnostic and therapeutic dressing (FDTD) based on modifiable poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS). By tuning the electrical conductivity of the PEDOT:PSS film (1 S/cm to 6.4 kS/cm) while maintaining a low Young’s modulus, we enable the versatile integration of temperature, impedance, and pH sensors alongside electrical and optical stimulators into a single, flexible dressing. Biosensing assays demonstrate high sensitivity (1 Ω/°C, −2 mV/10% volumetric water content, and −30 mV/pH), excellent linearity (<i>R</i><sup>2</sup> &gt; 0.99), and robust reproducibility. In vivo therapeutic efficacy, rigorously assessed using circular and square wound models in Sprague-Dawley rats, reveals that FDTD-mediated electro-optical synergistic therapy achieves greater than 98% wound closure within 8 days, significantly outperforming the control group (&lt;65%) and other reported physical therapies (≤90%). Mechanistically, accelerated regeneration is attributed to improved cellular proliferation, collagen organization, and neovascularization facilitated by electro-optical synergistic treatment. Furthermore, the integration of wireless power transfer and Bluetooth modules enables real-time data acquisition and remote therapeutic modulation, positioning FDTD as a promising platform for transformative wound management.</p><p></p>

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Modifiable PEDOT:PSS-based flexible diagnostic and therapeutic dressings for personalized wound management

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月23日

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  • Leyan Wang,
  • Guang Yao,
  • Siyuan Cai,
  • Xingyi Gan,
  • Yuxin Gan,
  • Xuhan Ren,
  • Chenzheng Zhou,
  • Taisong Pan,
  • Min Gao,
  • Binbin Jiang,
  • Zongkai Yan,
  • Jia Zhu,
  • Zhenlong Huang,
  • Yuan Lin

摘要

Intelligent wound management necessitates flexible and personalized wound dressings capable of real-time physiological monitoring and targeted therapeutic interventions. A significant challenge lies in integrating diverse sensing and stimulation components into an all-in-one dressing while maintaining material compatibility and structural interoperability. Here, we present a sophisticated and scalable flexible diagnostic and therapeutic dressing (FDTD) based on modifiable poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS). By tuning the electrical conductivity of the PEDOT:PSS film (1 S/cm to 6.4 kS/cm) while maintaining a low Young’s modulus, we enable the versatile integration of temperature, impedance, and pH sensors alongside electrical and optical stimulators into a single, flexible dressing. Biosensing assays demonstrate high sensitivity (1 Ω/°C, −2 mV/10% volumetric water content, and −30 mV/pH), excellent linearity (R2 > 0.99), and robust reproducibility. In vivo therapeutic efficacy, rigorously assessed using circular and square wound models in Sprague-Dawley rats, reveals that FDTD-mediated electro-optical synergistic therapy achieves greater than 98% wound closure within 8 days, significantly outperforming the control group (<65%) and other reported physical therapies (≤90%). Mechanistically, accelerated regeneration is attributed to improved cellular proliferation, collagen organization, and neovascularization facilitated by electro-optical synergistic treatment. Furthermore, the integration of wireless power transfer and Bluetooth modules enables real-time data acquisition and remote therapeutic modulation, positioning FDTD as a promising platform for transformative wound management.