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<p>Wound healing is influenced by local temperature. Sunlight-induced heating elevates wound temperature, which in turn exacerbates inflammation and infection risks, ultimately delaying regeneration. Despite this critical challenge, current dressings lack any capability for thermal protection. We present a bilayer radiative cooling dressing designed for passive cooling, antibacterial, and antioxidative protection. The top radiative cooling layer is a polyvinyl alcohol matrix with silicon dioxide nanoparticles and eugenol, while the bottom layer contains C-phycocyanin, a natural antioxidant and antibacterial agent. This dressing achieved a solar reflectance of 0.92 (0.3–2.5 μm) and thermal emissivity of 0.92 (8–13 μm), allowing effective heat dissipation. Under outdoor conditions, it maintained surface temperatures up to 15.2 °C below ambient. In a murine full-thickness wound model exposed to simulated sunlight, the dressing suppressed excessive heating (&lt;40 °C) and enhanced repair, achieving 90 ± 2% wound contraction, nearly twice that of a commercial adhesive bandage (47.97 ± 3.45%). These findings integrate passive radiative cooling with antioxidative and antibacterial agent delivery, offering thermal protection and accelerated regenerative healing under heat stress conditions.</p><p></p>

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Multifunctional bilayer radiative cooling dressing for regenerative wound healing under heat stress

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月13日

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  • Changhwan Hyeon,
  • Han Lee,
  • Woo-Seung Kim,
  • So-Min Kim,
  • Ki-Ju Kwon,
  • Juhoon Baek,
  • Minkyung Kim,
  • Ki-Jong Rhee,
  • Sunghee Hyun,
  • Dasol Lee

摘要

Wound healing is influenced by local temperature. Sunlight-induced heating elevates wound temperature, which in turn exacerbates inflammation and infection risks, ultimately delaying regeneration. Despite this critical challenge, current dressings lack any capability for thermal protection. We present a bilayer radiative cooling dressing designed for passive cooling, antibacterial, and antioxidative protection. The top radiative cooling layer is a polyvinyl alcohol matrix with silicon dioxide nanoparticles and eugenol, while the bottom layer contains C-phycocyanin, a natural antioxidant and antibacterial agent. This dressing achieved a solar reflectance of 0.92 (0.3–2.5 μm) and thermal emissivity of 0.92 (8–13 μm), allowing effective heat dissipation. Under outdoor conditions, it maintained surface temperatures up to 15.2 °C below ambient. In a murine full-thickness wound model exposed to simulated sunlight, the dressing suppressed excessive heating (<40 °C) and enhanced repair, achieving 90 ± 2% wound contraction, nearly twice that of a commercial adhesive bandage (47.97 ± 3.45%). These findings integrate passive radiative cooling with antioxidative and antibacterial agent delivery, offering thermal protection and accelerated regenerative healing under heat stress conditions.