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<p>Conventional optical probes suffer from signal degradation in aqueous media, hindering sensitive biodetection. To overcome this, newly developed water-insensitive down-shifting nanoparticles (WINPs) possess superior photophysical properties in the NIR-I window, including high quantum yield and negligible thermal effects, permitting stable, high-contrast signal generation under low excitation power. This advantage facilitated a low-power lateral flow assay capable of highly sensitive avian influenza virus (AIV) detection in the opaque biological matrices (such as avian swabs), mitigating interference issues relying on visible-range signals.</p>

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Water-insensitive down-shifting nanoparticles for sensitive biosensing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月5日

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  • Jiang Ming,
  • Sikun Hu,
  • Fan Zhang

摘要

Conventional optical probes suffer from signal degradation in aqueous media, hindering sensitive biodetection. To overcome this, newly developed water-insensitive down-shifting nanoparticles (WINPs) possess superior photophysical properties in the NIR-I window, including high quantum yield and negligible thermal effects, permitting stable, high-contrast signal generation under low excitation power. This advantage facilitated a low-power lateral flow assay capable of highly sensitive avian influenza virus (AIV) detection in the opaque biological matrices (such as avian swabs), mitigating interference issues relying on visible-range signals.