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<p>Owing to its unique ability to capture volumetric tomographic information with a single light flash, optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method’s scalability and the achievable spatial resolution are yet limited by the narrow bandwidth of piezo-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (0.3–40 MHz) sub mm<sup>2</sup> area elements, thus enabling real-time multi-scale volumetric imaging with 22–35 µm spatial resolution, superior image fidelity and over an order of magnitude signal-to-noise enhancement compared to piezo-composite equivalents. We further demonstrate five-dimensional (spectroscopic, time-resolved, volumetric) imaging capabilities by visualizing fast stimulus-evoked cerebral oxygenation changes in mice and performing real-time functional angiography of deep human micro-vasculature. The new technology thus leverages the true potential of OA for quantitative high-resolution visualization of rapid bio-dynamics across scales.</p>

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Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月7日

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  • Pavel V. Subochev,
  • Xosé Luís Deán-Ben,
  • Zhenyue Chen,
  • Maxim B. Prudnikov,
  • Vladimir A. Vorobev,
  • Alexey A. Kurnikov,
  • Anna G. Orlova,
  • Anna S. Postnikova,
  • Alexey V. Kharitonov,
  • Mikhail D. Proyavin,
  • Roman I. Ovsyannikov,
  • Anatoly G. Sanin,
  • Mikhail Y. Kirillin,
  • Francisco Montero de Espinosa,
  • Ilya V. Turchin,
  • Daniel Razansky

摘要

Owing to its unique ability to capture volumetric tomographic information with a single light flash, optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method’s scalability and the achievable spatial resolution are yet limited by the narrow bandwidth of piezo-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (0.3–40 MHz) sub mm2 area elements, thus enabling real-time multi-scale volumetric imaging with 22–35 µm spatial resolution, superior image fidelity and over an order of magnitude signal-to-noise enhancement compared to piezo-composite equivalents. We further demonstrate five-dimensional (spectroscopic, time-resolved, volumetric) imaging capabilities by visualizing fast stimulus-evoked cerebral oxygenation changes in mice and performing real-time functional angiography of deep human micro-vasculature. The new technology thus leverages the true potential of OA for quantitative high-resolution visualization of rapid bio-dynamics across scales.