Scholarlink

<p>Genomic alterations of <i>IKZF1</i> are common and associated with adverse clinical features in B-progenitor acute lymphoblastic leukemia (B-ALL). The relationship between the type of <i>IKZF1</i> alteration, B-ALL genomic subtype and outcome are incompletely understood. B-ALL subtype and genomic alterations were determined using transcriptome and genomic sequencing, and SNP microarray analysis in 688 pediatric patients with B-ALL in the St. Jude Total Therapy XV and 16 studies. <i>IKZF1</i> alterations were identified in 115 (16.7%) patients, most commonly in <i>BCR::ABL1</i> (78%) and <i>CRLF2-</i>rearranged, <i>BCR::ABL1-</i>like B-ALL (70%). These alterations were associated with 5-year cumulative incidence of relapse (CIR) of 14.8 ± 3.3% compared to 5.0 ± 0.9% for patients without any <i>IKZF1</i> alteration (<i>P</i> &lt; 0.0001). In separate multivariable analyses adjusting for genetic subtype groups and other factors, <i>IKZF1</i> deletions of exons 4–7 (<i>P</i> = 0.0002), genomic <i>IKZF1</i><sup>plus</sup> with any <i>IKZF1</i> deletion (<i>P</i> = 0.006) or with focal <i>IKZF1</i> deletion (<i>P</i> = 0.0007), and unfavorable genomic subtypes (<i>P</i> &lt; 0.005) were independently adverse prognostic factors. Associations of genomic <i>IKZF1</i><sup>plus</sup> and exon 4–7 deletions with adverse outcomes were confirmed in an independent cohort. The type of <i>IKZF1</i> alteration, together with the subtype, are informative for risk stratification and to predict response in patients with B-ALL.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Heterogeneity of IKZF1 genomic alterations and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia

  • 期刊论文

  • 发表日期：

    2025年5月13日

查看全文
  • Ruth W. Wang’ondu,
  • Emily Ashcraft,
  • Ti-Cheng Chang,
  • Kathryn G. Roberts,
  • Samuel W. Brady,
  • Yiping Fan,
  • William Evans,
  • Mary V. Relling,
  • Kristine R. Crews,
  • Jun Yang,
  • Wenjian Yang,
  • Stanley Pounds,
  • Gang Wu,
  • Meenakshi Devidas,
  • Kelly Maloney,
  • Leonard Mattano,
  • Reuven J. Schore,
  • Anne Angiolillo,
  • Eric Larsen,
  • Wanda Salzer,
  • Michael J. Burke,
  • Mignon L. Loh,
  • Sima Jeha,
  • Ching-Hon Pui,
  • Hiroto Inaba,
  • Cheng Cheng,
  • Charles G. Mullighan

摘要

Genomic alterations of IKZF1 are common and associated with adverse clinical features in B-progenitor acute lymphoblastic leukemia (B-ALL). The relationship between the type of IKZF1 alteration, B-ALL genomic subtype and outcome are incompletely understood. B-ALL subtype and genomic alterations were determined using transcriptome and genomic sequencing, and SNP microarray analysis in 688 pediatric patients with B-ALL in the St. Jude Total Therapy XV and 16 studies. IKZF1 alterations were identified in 115 (16.7%) patients, most commonly in BCR::ABL1 (78%) and CRLF2-rearranged, BCR::ABL1-like B-ALL (70%). These alterations were associated with 5-year cumulative incidence of relapse (CIR) of 14.8 ± 3.3% compared to 5.0 ± 0.9% for patients without any IKZF1 alteration (P < 0.0001). In separate multivariable analyses adjusting for genetic subtype groups and other factors, IKZF1 deletions of exons 4–7 (P = 0.0002), genomic IKZF1plus with any IKZF1 deletion (P = 0.006) or with focal IKZF1 deletion (P = 0.0007), and unfavorable genomic subtypes (P < 0.005) were independently adverse prognostic factors. Associations of genomic IKZF1plus and exon 4–7 deletions with adverse outcomes were confirmed in an independent cohort. The type of IKZF1 alteration, together with the subtype, are informative for risk stratification and to predict response in patients with B-ALL.