Objective <p>Infants with bronchopulmonary dysplasia (BPD) discharged on supplemental oxygen have complex care needs after discharge. This study explored the impact of a comprehensive BPD clinic on respiratory and growth outcomes, resource utilization, and healthcare expenditures for patients with BPD discharged home on oxygen.</p> Study design <p>We performed a retrospective study of 86 infants with moderate or severe BPD discharged on supplemental oxygen who were followed in a routine neonatal follow-up clinic or in a comprehensive BPD clinic with neonatology and pulmonary services. Outcomes were compared using univariate analyses.</p> Results <p>Despite the higher complexity of the patients in the comprehensive clinic group, there were fewer unplanned non-ICU admissions and respiratory-related readmissions compared to patients in the neonatal follow-up group. The median number of emergency department visits and total healthcare expenditures were similar between groups.</p> Conclusions <p>Comprehensive follow-up reduces readmissions without increasing healthcare costs for infants with BPD discharged home on supplemental oxygen.</p>