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<p>Internalizing disorders in children and adolescents include anxiety, depression, and somatic symptoms. Early identification is essential to prevent long-term mental health challenges. Hypoxic-ischemic encephalopathy (HIE) has been associated with an increased risk of internalizing disorders in early life. This scoping review summarized the literature on internalizing disorders in HIE survivors, highlighting the assessment methods and psychological outcomes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for scoping reviews and included peer-reviewed studies reporting internalizing symptoms in HIE survivors. Five major databases were searched, and study quality was assessed using the Newcastle–Ottawa Scale. Of the 2917 studies screened, twelve met the inclusion criteria. Our review revealed variability in internalizing symptoms, but nine of the 12 studies showed that HIE survivors had higher internalizing symptoms. This review revealed substantial variability across studies, underscoring the need for more standardized assessment tools and early screening during early childhood.</p>

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Silent struggles of internalizing disorders in survivors of neonatal hypoxic ischemic encephalopathy: a scoping review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Nursena Yabalar,
  • Irem Isik,
  • Nur Aycan,
  • Mary Hitchcock,
  • Sarah Elizabeth Nigro,
  • Alanna M. Kessler-Jones,
  • Pelin Cengiz,
  • Jonathan J. Mietchen

摘要

Internalizing disorders in children and adolescents include anxiety, depression, and somatic symptoms. Early identification is essential to prevent long-term mental health challenges. Hypoxic-ischemic encephalopathy (HIE) has been associated with an increased risk of internalizing disorders in early life. This scoping review summarized the literature on internalizing disorders in HIE survivors, highlighting the assessment methods and psychological outcomes. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for scoping reviews and included peer-reviewed studies reporting internalizing symptoms in HIE survivors. Five major databases were searched, and study quality was assessed using the Newcastle–Ottawa Scale. Of the 2917 studies screened, twelve met the inclusion criteria. Our review revealed variability in internalizing symptoms, but nine of the 12 studies showed that HIE survivors had higher internalizing symptoms. This review revealed substantial variability across studies, underscoring the need for more standardized assessment tools and early screening during early childhood.