Scholarlink

Objective <p>To determine the incidence of necrotizing enterocolitis (NEC) among extremely premature infants (EPI: gestational age &lt;28 weeks) fed a base exclusive human milk diet (EHMD) as a function of human-milk fortifier (human milk-based: HM-HMF or bovine milk-based: BM-HMF).</p> Study design <p>Retrospective cohort of 703 EPI, 355 at Wolfson Children’s Hospital fed an EHMD with BM-HMF and 348 at UF Health Hospital fed an EHMD with HM-HMF fortification under similar feeding protocols. The outcomes of interest were NEC ≥&#xa0;stage II, surgical NEC, and mortality.</p> Results <p>Baseline characteristics were similar between the groups. NEC occurred in 9.5% of HM-HMF and 6.5% of BM-HMF fortified EPI [adjusted OR: 1.48 (0.83–2.63); <i>p</i> = 0.18]. Similarly, no differences were found in rates of surgical NEC or mortality or age at NEC onset.</p> Conclusion <p>In this large retrospective study in EPI, we did not detect any signal that fortification with HM-HMF reduced NEC incidence compared with BM-HMF supplementation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparing necrotizing enterocolitis risk among extremely preterm infants by use of human-milk or bovine-milk-based fortifier

  • 期刊论文

  • 发表日期：

    2026年7月6日

查看全文
  • Randhir Yadav,
  • Sireesha Nandula,
  • Henry Zapata,
  • Shumneva Shrestha,
  • Vasantha H. S. Kumar,
  • Shiva Gautam,
  • Mark L. Hudak,
  • Sanket D. Shah

摘要

Objective

To determine the incidence of necrotizing enterocolitis (NEC) among extremely premature infants (EPI: gestational age <28 weeks) fed a base exclusive human milk diet (EHMD) as a function of human-milk fortifier (human milk-based: HM-HMF or bovine milk-based: BM-HMF).

Study design

Retrospective cohort of 703 EPI, 355 at Wolfson Children’s Hospital fed an EHMD with BM-HMF and 348 at UF Health Hospital fed an EHMD with HM-HMF fortification under similar feeding protocols. The outcomes of interest were NEC ≥ stage II, surgical NEC, and mortality.

Results

Baseline characteristics were similar between the groups. NEC occurred in 9.5% of HM-HMF and 6.5% of BM-HMF fortified EPI [adjusted OR: 1.48 (0.83–2.63); p = 0.18]. Similarly, no differences were found in rates of surgical NEC or mortality or age at NEC onset.

Conclusion

In this large retrospective study in EPI, we did not detect any signal that fortification with HM-HMF reduced NEC incidence compared with BM-HMF supplementation.