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Objective <p>Investigate the impact of reticulocyte hemoglobin&#xa0;content (RetHe) on neurodevelopment in preterm infants.</p> Study Design <p>Retrospective cohort of infants born ≤36<sup>6/7</sup> weeks gestational age (GA) with neurodevelopmental testing post-discharge. Associations between neurodevelopment and average RetHe, lowest RetHe, and exposure time to low RetHe ( &lt; 29 pg) were described and stratified by GA. RetHe over time and test Z-scores were assessed using multivariable linear regression.</p> Results <p>52% of 381 infants (<i>N</i> = 199) had at least 1 low RetHe. Infants with abnormal development had lower average and minimum RetHe, and longer exposure to low RetHe (all <i>p</i> ≤ <i>0.003</i>). RetHe was highest in infants born 32–33 weeks GA. Higher RetHe during postnatal weeks 1-5 was associated with higher Test of Infant Motor Performance Z-scores (<i>p</i> = <i>0.0048</i>), with diminishing effect over time, but decreasing 12-month Bayley cognitive Z-scores (<i>p</i> = <i>0.0064</i>).</p> Conclusion <p>RetHe is associated with neurodevelopment and potentially has differential effects based on GA and postnatal age.</p>

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Association between reticulocyte hemoglobin content (RetHe) and neurodevelopmental outcomes in preterm infants

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月8日

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  • Grace K. Mueller,
  • Miheret Yitayew,
  • Amanda Robinson,
  • Roy Sabo,
  • Karen D. Hendricks-Muñoz

摘要

Objective

Investigate the impact of reticulocyte hemoglobin content (RetHe) on neurodevelopment in preterm infants.

Study Design

Retrospective cohort of infants born ≤366/7 weeks gestational age (GA) with neurodevelopmental testing post-discharge. Associations between neurodevelopment and average RetHe, lowest RetHe, and exposure time to low RetHe ( < 29 pg) were described and stratified by GA. RetHe over time and test Z-scores were assessed using multivariable linear regression.

Results

52% of 381 infants (N = 199) had at least 1 low RetHe. Infants with abnormal development had lower average and minimum RetHe, and longer exposure to low RetHe (all p ≤ 0.003). RetHe was highest in infants born 32–33 weeks GA. Higher RetHe during postnatal weeks 1-5 was associated with higher Test of Infant Motor Performance Z-scores (p = 0.0048), with diminishing effect over time, but decreasing 12-month Bayley cognitive Z-scores (p = 0.0064).

Conclusion

RetHe is associated with neurodevelopment and potentially has differential effects based on GA and postnatal age.