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Objective <p>To evaluate gestational age (GA)-specific associations between antenatal corticosteroid (ACS) exposure and early physiologic vulnerability and neonatal outcomes in preterm infants.</p> Study design <p>This retrospective cohort study used Korean Neonatal Network data and included infants born 2013–2021 with birth weight &lt;1500 g or GA &lt; 32 weeks. ACS exposure was categorized as complete, incomplete, or none. Multivariable logistic regression estimated adjusted odds ratios, with GA-stratified analyses and a prespecified subgroup of infants born at &lt;25 weeks.</p> Results <p>ACS exposure was associated with reduced need for advanced resuscitation at birth, reduced risk of severe intraventricular hemorrhage and decreased mortality, with the strongest associations before 32 weeks’ gestation. In infants born at &lt;25 weeks, any ACS exposure was associated with greater physiologic stability and improved survival versus no ACS exposure.</p> Conclusions <p>ACS exposure was associated with improved physiologic stability and survival in preterm infants, with benefits greater at lower GAs.</p>

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Gestational age-specific effects of antenatal corticosteroids on early physiologic vulnerability and neonatal outcomes

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • Abraham Kwak,
  • Chae Young Kim,
  • Juhee Park,
  • Tae-Gyeong Kim,
  • Kyusang Yoo,
  • Jung Il Kwak,
  • Joo Hyung Roh,
  • Jeong Min Lee,
  • Ha Na Lee,
  • Jiyoon Jeong,
  • Soo Hyun Kim,
  • Euiseok Jung,
  • Byong Sop Lee

摘要

Objective

To evaluate gestational age (GA)-specific associations between antenatal corticosteroid (ACS) exposure and early physiologic vulnerability and neonatal outcomes in preterm infants.

Study design

This retrospective cohort study used Korean Neonatal Network data and included infants born 2013–2021 with birth weight <1500 g or GA < 32 weeks. ACS exposure was categorized as complete, incomplete, or none. Multivariable logistic regression estimated adjusted odds ratios, with GA-stratified analyses and a prespecified subgroup of infants born at <25 weeks.

Results

ACS exposure was associated with reduced need for advanced resuscitation at birth, reduced risk of severe intraventricular hemorrhage and decreased mortality, with the strongest associations before 32 weeks’ gestation. In infants born at <25 weeks, any ACS exposure was associated with greater physiologic stability and improved survival versus no ACS exposure.

Conclusions

ACS exposure was associated with improved physiologic stability and survival in preterm infants, with benefits greater at lower GAs.