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Objective <p>Describe rates of intraventricular hemorrhage (IVH) in the VentFirst cohort, model risks for severe IVH and compare IVH rates to a contemporaneous population.</p> Study design <p>Sub-analysis of the VentFirst multi-center randomized trial.</p> Results <p>Head ultrasound findings from 548 infants &lt;29 weeks’ gestation who survived to first head ultrasound study in the VentFirst trial were analyzed. Any grade of IVH was found in 31% and severe (grade III/ IV) IVH in 8%. Logistic regression indicated gestational age (GA), twin gestation and 1-minute Apgar as risks for severe IVH. Odds of any IVH and severe IVH were lower in the VentFirst population than in a comparable population in the Vermont Oxford Network.</p> Conclusion <p>Severe IVH in the VentFirst trial was associated with low GA, twin gestation and low 1-minute Apgar score. The lower odds of IVH for the study cohort compared to a similar population may reflect optimized delivery conditions.</p> Trial registration <p>ClinicalTrials.gov Identifier: NCT02742454</p>

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Rates and predictors of intraventricular hemorrhage in the ventfirst trial with comparison to a contemporaneous cohort

  • 期刊论文

  • 发表日期：

    2026年6月22日

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  • Marya L. Strand,
  • Dorothy I. Bulas,
  • Susan Niermeyer,
  • Jennifer L. Fang,
  • Jamie B. Warren,
  • Justin B. Josephsen,
  • Monica Epelman,
  • Beth M. Kline-Fath,
  • Gina R. Petroni,
  • Karen D. Fairchild

摘要

Objective

Describe rates of intraventricular hemorrhage (IVH) in the VentFirst cohort, model risks for severe IVH and compare IVH rates to a contemporaneous population.

Study design

Sub-analysis of the VentFirst multi-center randomized trial.

Results

Head ultrasound findings from 548 infants <29 weeks’ gestation who survived to first head ultrasound study in the VentFirst trial were analyzed. Any grade of IVH was found in 31% and severe (grade III/ IV) IVH in 8%. Logistic regression indicated gestational age (GA), twin gestation and 1-minute Apgar as risks for severe IVH. Odds of any IVH and severe IVH were lower in the VentFirst population than in a comparable population in the Vermont Oxford Network.

Conclusion

Severe IVH in the VentFirst trial was associated with low GA, twin gestation and low 1-minute Apgar score. The lower odds of IVH for the study cohort compared to a similar population may reflect optimized delivery conditions.

Trial registration

ClinicalTrials.gov Identifier: NCT02742454