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Objectives <p>To compare the incidence of meconium aspiration syndrome (MAS) among neonates born through meconium-stained amniotic fluid (MSAF) before and after discontinuation of endotracheal suctioning for non-vigorous neonates.</p> Methods <p>We conducted a multicenter retrospective cohort study across three centers comparing two eras. Neonates born through MSAF at ≥36 weeks’ gestation were included. Multivariable regression adjusted for sex and birth center.</p> Results <p>Among 8635 neonates (5554 Era 1; 3081 Era 2), including 1053 non-vigorous neonates, unadjusted MAS incidence did not differ between eras overall (4.8% vs. 5.5%, <i>p</i> = 0.17) or among non-vigorous neonates (21.0% vs. 22.8%, <i>p</i> = 0.55). After adjustment, Era 2 was associated with higher odds of MAS overall (aOR 1.37, 95% CI 1.11–1.69) and among non-vigorous neonates (aOR 1.54, 95% CI 1.07–2.22). Respiratory distress was higher in Era 2, while other outcomes assessed were unchanged.</p> Conclusions <p>Discontinuation of routine suctioning was associated with increased MAS incidence among neonates born through MSAF.</p>

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Comparison of neonatal outcomes of term neonates with meconium-stained amniotic fluid before and after routine endotracheal suctioning strategy at birth

  • 期刊论文

  • 发表日期：

    2026年3月31日

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  • Sanjay Chawla,
  • Rachel G. Greenberg,
  • Praveen Kumar Boddu,
  • Anup Katheria,
  • Katherine Coughlin,
  • Kanika Deora,
  • Gary Weiner,
  • Henry C. Lee,
  • Vaneet Kalra,
  • Arpitha Chiruvolu,
  • Thomas Wiswell,
  • Satyan Lakshminrusimha

摘要

Objectives

To compare the incidence of meconium aspiration syndrome (MAS) among neonates born through meconium-stained amniotic fluid (MSAF) before and after discontinuation of endotracheal suctioning for non-vigorous neonates.

Methods

We conducted a multicenter retrospective cohort study across three centers comparing two eras. Neonates born through MSAF at ≥36 weeks’ gestation were included. Multivariable regression adjusted for sex and birth center.

Results

Among 8635 neonates (5554 Era 1; 3081 Era 2), including 1053 non-vigorous neonates, unadjusted MAS incidence did not differ between eras overall (4.8% vs. 5.5%, p = 0.17) or among non-vigorous neonates (21.0% vs. 22.8%, p = 0.55). After adjustment, Era 2 was associated with higher odds of MAS overall (aOR 1.37, 95% CI 1.11–1.69) and among non-vigorous neonates (aOR 1.54, 95% CI 1.07–2.22). Respiratory distress was higher in Era 2, while other outcomes assessed were unchanged.

Conclusions

Discontinuation of routine suctioning was associated with increased MAS incidence among neonates born through MSAF.